CGP 35348

(HB0955)
Technical documents: SDS CoA Datasheet
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Biological Data

Biological description Selective GABAB receptor antagonist (IC50 = 34 µM). Improves learning and neuromuscular function in a model of ischemia. Shows pro-epileptic actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (3-Aminopropyl)(diethoxymethyl)phosphinic acid
Molecular Weight 225.22
Chemical structure CGP 35348  [123690-79-9] Chemical Structure
Molecular Formula C8H20NO4P
CAS Number 123690-79-9
PubChem identifier 107699
SMILES NCCCP(C(OCC)OCC)(O)=O
InChiKey QIIVUOWTHWIXFO-UHFFFAOYSA-N

References for CGP 35348

References are publications that support the biological activity of the product
  • CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.

    Gillani Q et al (2014) Biomed Res Int 2014 : 295215
  • Involvement of GABA(B) receptors in convulsant-induced epileptiform activity in rat neocortex in vitro.

    Sutor B et al (1998) Eur J Neurosci 10(11) : 3417-27.
  • CGP 35348: a centrally active blocker of GABAB receptors.

    Olpe HR et al (1990) Eur J Pharmacol 187(1) : 27-38.

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