Product overview

Name Angiotensin II (human)
Biological description

Angiotensin II is a peptide endocrine hormone which is involved in a variety of biological processes.

Angiotensin II is the primary effector of the RAS (renin-angiotensin system) which is a central component of the physiological/ pathophysiological responses of the cardiovascular system.

Stimulation with angiotensin II modulates blood pressure and regulates vasoconstriction and salt/water homeostasis.

Angiotensin II is also associated with induction of smooth muscle cell growth.


Angiotensin II is also involved in the inflammatory process. It is considered a growth factor that regulates cell growth and fibrosis. It increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on various cell types (e.g. leucocytes, endothelial cells and vascular smooth muscle cells).

Angiotensin II is also a substrate for ACE2.

Alternative names AngII, Ang-II, Ang II
Purity >95%
Description Endogenous peptide hormone. Potent vasoconstrictor.
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name DRVYIHPF
Molecular Weight 1046.2
Chemical structure Angiotensin II (human) [4474-91-3] Chemical Structure
Molecular Formula C50H71N13O12
Sequence (one letter) DRVYIHPF
Sequence (three letter) Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
CAS Number 4474-91-3
PubChem identifier 172198
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
Protein length 8

References for Angiotensin II (human)

References are publications that support the biological activity of the product
  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
  • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

    Mehta et al (2007) Am J Physiol Cell Physiol 292(1) : 82-97
  • Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade.

    Dandona et al (2007) J Hum Hypertens. 21(1) : 20-7
  • Inflammation and angiotensin II.

    Suzuki et al (2003) Int J Biochem Cell Biol 35(6) : 881-900

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