Product overview

Name Angiotensin II (human)
Biological description

Angiotensin II is a peptide endocrine hormone which is involved in a variety of biological processes.


Angiotensin II is the primary effector of the RAS (renin-angiotensin system) which is a central component of the physiological/ pathophysiological responses of the cardiovascular system.

Stimulation with angiotensin II modulates blood pressure and regulates vasoconstriction and salt/water homeostasis.

Angiotensin II is also associated with induction of smooth muscle cell growth.

 


Angiotensin II is also involved in the inflammatory process. It is considered a growth factor that regulates cell growth and fibrosis. It increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on various cell types (e.g. leucocytes, endothelial cells and vascular smooth muscle cells).

Angiotensin II is also a substrate for ACE2.

Alternative names AngII, Ang-II, Ang II
Purity >95%
Description Endogenous peptide hormone. Potent vasoconstrictor.
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name DRVYIHPF
Molecular Weight 1046.2
Chemical structure Angiotensin II (human) [4474-91-3] Chemical Structure
Molecular Formula C50H71N13O12
Sequence (one letter) DRVYIHPF
Sequence (three letter) Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
CAS Number 4474-91-3
PubChem identifier 172198
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChiKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Protein length 8

References for Angiotensin II (human)

References are publications that support the biological activity of the product
  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
  • Angiotensin II revisited: new roles in inflammation, immunology and aging.

    Benigni et al (2010) EMBO Mol Med. 7 : 247-57
  • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.

    Mehta et al (2007) Am J Physiol Cell Physiol 292(1) : 82-97
  • Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade.

    Dandona et al (2007) J Hum Hypertens. 21(1) : 20-7
  • Inflammation and angiotensin II.

    Suzuki et al (2003) Int J Biochem Cell Biol 35(6) : 881-900

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