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Biological Data

Biological description Potent and selective TRPV1 channel antagonist (IC50 values are 6.0 and 35 nM for acid- and capsaicin-induced TRPV1 channels respectively). Also potent TRPM8 channel antagonist (IC50 = 143 nM). Blood brain barrier permeable. Displays analgesic properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM) and in ethanol (40mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Molecular Weight 372.89
Chemical structure BCTC  [393514-24-4] Chemical Structure
Molecular Formula C20H25ClN4O
CAS Number 393514-24-4
PubChem identifier 9929425
InChi InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
MDL number MFCD08690556

References for BCTC

References are publications that support the biological activity of the product
  • Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.

    Benko R et al (2012) Eur J Pharmacol 674(1) : 44-50.
  • Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.

    Weil A et al (2005) Mol Pharmacol 68(2) : 518-27.
  • N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath

    Pomonis JD et al (2003) J Pharmacol Exp Ther 306(1) : 387-93.
  • N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

    Valenzano KJ et al (2003) J Pharmacol Exp Ther 306(1) : 377-86.

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