Potent and selective TRPV1 channel antagonist (IC50 values are 6.0 and 35 nM for acid- and capsaicin-induced TRPV1 channels respectively). Also potent TRPM8 channel antagonist (IC50 = 143 nM). Blood brain barrier permeable. Displays analgesic properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (100mM) and in ethanol (40mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Pomonis JD et al (2003) J Pharmacol Exp Ther 306(1) : 387-93.
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Valenzano KJ et al (2003) J Pharmacol Exp Ther 306(1) : 377-86.
![BCTC [393514-24-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1190.png "BCTC [393514-24-4]")
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