BCTC

Name: BCTC
Brand: Hello Bio
SKU: HB1190
Price: 97 USD
Availability: InStock

(HB1190)

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Technical documents: SDS Datasheet

Product overview

Name

BCTC

Purity

>98%

Description

Potent, selective TRPV1 channel antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Images

BCTC product vial image | Hello Bio

Biological Data

Biological description

Potent and selective TRPV1 channel antagonist (IC₅₀ values are 6.0 and 35 nM for acid- and capsaicin-induced TRPV1 channels respectively). Also potent TRPM8 channel antagonist (IC₅₀ = 143 nM). Blood brain barrier permeable. Displays analgesic properties.

Solubility & Handling

Storage instructions

Room temperature

Solubility overview

Soluble in DMSO (100mM) and in ethanol (40mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide

Molecular Weight

372.89

Chemical structure

Molecular Formula

C₂₀H₂₅ClN₄O

CAS Number

393514-24-4

PubChem identifier

9929425

SMILES

CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl

InChi

InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)

InChiKey

ROGUAPYLUCHQGK-UHFFFAOYSA-N

MDL number

MFCD08690556

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for BCTC

References are publications that support the biological activity of the product

Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.
Benko R et al (2012) Eur J Pharmacol 674(1) : 44-50.
Read more (PubMedID: 22056835)
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.
Weil A et al (2005) Mol Pharmacol 68(2) : 518-27.
Read more (PubMedID: 15911692)
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Pomonis JD et al (2003) J Pharmacol Exp Ther 306(1) : 387-93.
Read more (PubMedID: 12721336)
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Valenzano KJ et al (2003) J Pharmacol Exp Ther 306(1) : 377-86.
Read more (PubMedID: 12721338)

Grouped product items
Order: HB1190
Pack	Price	Qty
5mg	$97
10mg	$141
50mg	$565

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Potent, selective TRPV1 channel antagonist

BCTC

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for BCTC

Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.

Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.

N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

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BCTC

Product overview

Images

BCTC product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for BCTC

Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.

Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.

N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.

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