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Biological Data
| Biological description | Antibiotic. Inhibits 50S ribosomal subunit formation and elongation during transpeptidation to interfere with protein synthesis.
Orally active and shows improved pharmacokinetics over erythromycin in mouse models.
Also inhibits autophagy.
Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.
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Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one |
| Chemical structure | ![Azithromycin [83905-01-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Azithromycin [83905-01-5]") |
| Molecular Formula | C38H72N2O12 |
| PubChem identifier | 447043 |
| SMILES | [H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1 |
| InChi | InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29 |
| InChiKey | MQTOSJVFKKJCRP-BICOPXKESA-N |
| Appearance | White to off-white |
References for Azithromycin
References are publications that support the biological activity of the product
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Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance
Choudhary R et al (2020) New Microbes New Infect : 100684 -
Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent
De Groote MA et al (2018) Front Microbiol 9 : 2231 -
The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin
Broad J et al (2013) Br J Pharmacol 168(8) : 1859-67
Antibiotic and protein synthesis inhibitor
![Azithromycin [83905-01-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4336.png "Azithromycin [83905-01-5]")
Understanding purity and quality - a guide for life scientists
