Product overview

Name Azithromycin
Alternative names CP 62993
Purity >98%
Description Antibiotic and protein synthesis inhibitor
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Biological Data

Biological description

Antibiotic. Inhibits 50S ribosomal subunit formation and elongation during transpeptidation to interfere with protein synthesis.

Orally active and shows improved pharmacokinetics over erythromycin in mouse models.

Also inhibits autophagy.

Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Molecular Weight 748.98
Chemical structure Azithromycin [83905-01-5] Chemical Structure
Molecular Formula C38H72N2O12
CAS Number 83905-01-5
PubChem identifier 447043
SMILES [H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1
InChi InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29
InChiKey MQTOSJVFKKJCRP-BICOPXKESA-N
MDL number MFCD00873574
Appearance White to off-white

References for Azithromycin

References are publications that support the biological activity of the product
  • Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

    Choudhary R et al (2020) New Microbes New Infect : 100684
  • Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent

    De Groote MA et al (2018) Front Microbiol 9 : 2231
  • The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin

    Broad J et al (2013) Br J Pharmacol 168(8) : 1859-67

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