Aminonucleoside antibiotic which disrupts peptide transfer on ribosomes on both prokaryotic and eukaryotic ribosomes to cause premature chain termination during translation.
It inhibits protein transport of into the mitochondria and also induces apoptosis and shows antineoplastic and antibacterial activity.
It is widely used as a selection antibiotic in cell culture. Puromycin allows the selection of cells that contain the puromycin N-acetyl-transferase gene (PAC) resistance gene.
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100 mM) and water (100 mM)
Handling
This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the solid material and any solutions in the dark and protecting from light.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Dipeptidyl arylamidase II of the pituitary. Properties of lysylalanyl-beta-naphthylamide hydrolysis: inhibition by cations, distribution in tissues, and subcellular localization.
McDonald et al (1968) J Biol Chem 243(8) : 2028-37
Understanding purity and quality - a guide for life scientists
