Product overview

Name A11
Biological description

ANXA1 (Annexin A1) derived peptide. Blocks the competition of ANXA1 with the E3 ubiquitin ligase Cbl for EpHA2 binding, leading to downregulation of EphA2 expression and inhibition of nasopharyngeal carcinoma (NPC) growth and metastasis.

Purity >95%
Description

ANXA1 (Annexin A1) derived peptide. Blocks ANXA1-EphA2 interaction.

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Solubility & Handling

Storage instructions -20°C
Solubility overview

Soluble in aqueous buffer

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 2767.19
Molecular Formula C117H204N46O32
Sequence (one letter) YGRKKRRQRRREYVQTVKSSKG
Sequence (three letter) H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH

References for A11

References are publications that support the biological activity of the product
  • ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis

    Feng J et al (2020) Cancer Res 80(20) : 4386-4398

1 Item

Publications
These publications cite the use of A11 purchased from Hello Bio:
  • ANXA1-derived peptide for targeting PD-L1 degradation inhibits tumor immune evasion in multiple cancers.

    Yu ZZ et al (2023) Journal for immunotherapy of cancer 11
    PubMedID: 37001908

1 Item