Product overview

Name Vigabatrin
Description Selective, irreversible GABA-T (transaminase) inhibitor
Alternative names (±)-γ-Vinyl GABA
Purity >98%
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Biological Data

Biological description Selective and irreversible GABA-T (transaminase) inhibitor. Inhibits GABA catabolism. Increases GABA levels in the brain and CSF while decreasing glutamate in a dose-dependent manner. Shows anticonvulsant and antidepressant actions.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-Aminohexenoic acid
Molecular Weight 129.16
Chemical structure Vigabatrin  [68506-86-5] Chemical Structure
Molecular Formula C6H11NO2
CAS Number 68506-86-5
PubChem identifier 5665
SMILES NC(C=C)CCC(O)=O
InChiKey PJDFLNIOAUIZSL-UHFFFAOYSA-N

References for Vigabatrin

References are publications that support the biological activity of the product
  • Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity.

    Russo E et al (2011) Behav Brain Res 225(1) : 373-6.
  • Effects of vigabatrin (gamma-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats.

    Halonen T et al (1991) Epilepsia 32(2) : 242-9.
  • Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes.

    Larsson OM et al (1986) Neuropharmacology 25(6) : 617-25.