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Biological Data
| Biological description | Selective angiotensin AT1 antagonist (IC50 = 44.9 nM) that displays ~30,000-fold selectivity over AT2 receptors.
Shows anti-hypertensive effects.
Recently investigated as part of COVID-19 compound repurposing. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | (S)-3-methyl-2-(N-{[2'-(2H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl]methyl}pentanamido)butanoic acid |
| Chemical structure | ![Valsartan [137862-53-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Valsartan [137862-53-4]") |
| Molecular Formula | C24H29N5O3 |
| SMILES | CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O |
| InChi | InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 |
| InChiKey | ACWBQPMHZXGDFX-QFIPXVFZSA-N |
References for Valsartan
References are publications that support the biological activity of the product
-
Valsartan: more than a decade of experience
Black HR et al (2009) Drugs 69(17) : 2393-414 -
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype
Criscione L et al (1993) Br J Pharmacol 110(2) : 761-71
Selective angiotensin AT1 antagonist
![Valsartan [137862-53-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3381_1.png "Valsartan [137862-53-4]")
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