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Biological Data

Biological description Potent, selective and ATP-competitive mTOR inhibitor (IC50 vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one
Molecular Weight 607.62
Molecular Formula C35H28F3N5O2
CAS Number 1222998-36-8
PubChem identifier 49836027
SMILES O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2
InChiKey AKCRNFFTGXBONI-UHFFFAOYSA-N

References for Torin 1

References are publications that support the biological activity of the product
  • Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.

    Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62
  • Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

    Liu et al (2010) J Med CHem 53(19) : 7146-55
  • An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

    Thoreen et al (2009) J Biol Chem 284(12) : 8023-32

3 Item(s)