Product overview
| Name | Torin 1 |
| Description | Potent, selective mTOR inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Potent, selective and ATP-competitive mTOR inhibitor (IC50 vales are 2 and 10 nM at mTORC1 and mTORC2 respectively). Exhibits 1000-fold selecticity for mTOR over PI3K and ~100-fold selectivity when compared to 450 other protein kinases. Impairs cell growth and proliferation to a greater degree than rapamycin. |
Solubility & Handling
| Storage instructions | +4°C |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | 1-[4-[4-(1-Oxopropyl)-1-piperazinyl ]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz o[h]-1,6-naphthyridin-2(1H)-one |
| Molecular Weight | 607.62 |
| Molecular Formula | C35H28F3N5O2 |
| CAS Number | 1222998-36-8 |
| PubChem identifier | 49836027 |
| SMILES | O=C(N5C6=CC(C(F)(F)F)=C(N7CCN(C(CC)=O)CC7)C=C6)C=CC2=C5C1=CC(C3=CN=C(C=CC=C4)C4=C3)=CC=C1N=C2 |
| InChiKey | AKCRNFFTGXBONI-UHFFFAOYSA-N |
References for Torin 1
References are publications that support the biological activity of the product
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Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
Francipane and Lagasse (2013) Oncotarget 4(11) : 1948-62 -
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.
Liu et al (2010) J Med CHem 53(19) : 7146-55 -
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Thoreen et al (2009) J Biol Chem 284(12) : 8023-32
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