Tiagabine hydrochloride product vial image | Hello Bio
Tiagabine hydrochloride product vial image | Hello Bio
Biological Data
Biological description
Selective GAT-1 GABA uptake inhibitor (IC50 = 67 nM). Selective for GAT-1 over mGAT2, mGAT3 and mGAT4 (IC50 values are 0.8, 300, >300 and 800 µM respectively). Shows anticonvulsive, antinociceptive, anxiolytic and antidepressant actions. Blood-brain barrier permeable.
Solubility & Handling
Solubility overview
Soluble in water (50mM) and in DMSO (100mM)
Storage instructions
Room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.
Thoeringer CK et al (2010) J Psychopharmacol 24(5) : 733-43.
Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkyla
White HS et al (2002) J Pharmacol Exp Ther 302(2) : 636-44.
![Tiagabine hydrochloride [145821-59-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0978.png "Tiagabine hydrochloride [145821-59-6]")
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