Product overview

Name TFLLR-NH2
Biological description TFLLR-NH2 is a selective PAR1 (protease-activated receptor-1) activating peptide. It is commonly used to activate platelets and has also been shown to elicit scratching in mice. Active in vivo.
Alternative names TFLLR, TF-NH2
Purity >95%
Description Selective PAR1 activating peptide
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Purity >95%
Chemical name TFLLR (modifications: C-terminal amide)
Molecular Weight 647.82
Chemical structure TFLLR-NH2 | [197794-83-5] Chemical Structure
Molecular Formula C76H104N18O19S2
Sequence (one letter) TFLLR
Modifications C-terminal amide
CAS Number 197794-83-5
PubChem identifier 10146183
SMILES C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)N)O
InChiKey ANAMCEKSRDPIPX-GFGQVAFXSA-N
MDL number MFCD05663482

References for TFLLR-NH2

References are publications that support the biological activity of the product
  • Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620.

    Jia et al (26718652) Oncol Rep 35(2) : 1222
  • Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice.

    Tsujii et al (2008) J Pharmacol Sci. 108(3) : 385-8
  • A role for proteinase-activated receptor-1 in inflammatory bowel diseases.

    Vergnolle et al (2004) J Clin Ivest. 114(10) : 1444-56

3 Item(s)