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TAT-Gap19

(HB9841)
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Technical documents: CoA Datasheet

Product overview

Name TAT-Gap19
Purity >95%
Description Cx43 hemichannel blocker. Active in vivo.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Cx43 hemichannel blocker. Inhibits astroglial Cx43 hemichannels in a dose-dependent manner, without affecting gap junction channels and reduces mitochondrial potassium influx. Also reduces intracellular ROS generation, cell death, inflammation and premature cell senescence.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
Molecular Weight 2703.28
Molecular Formula C119H212N46O26
CAS Number 1507930-54-2
PubChem identifier 127021051
SMILES [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O
Source Synthetic
InChiKey ALNCFPIRTLVJPY-XELKYWHDNA-N

References for TAT-Gap19

References are publications that support the biological activity of the product

  • Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

    Lissoni A et al (2020) International journal of molecular sciences 21 :
    Read more (PubMedID: 33027889)

  • Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

    Ramadan R et al (2020) Frontiers in pharmacology 11 : 212
    Read more (PubMedID: 32210810)

  • The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

    Abudara V et al (2014) Frontiers in cellular neuroscience 8 : 306
    Read more (PubMedID: 25374505)

3 Item(s)

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Grouped product items
Order: HB9841
Pack PriceQty
1mg
$200
Cx43 hemichannel blocker. Active in vivo.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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