TAT-Gap19

Name: TAT-Gap19
Brand: hello bio
SKU: HB9841
Price: 200 USD
Availability: InStock

(HB9841)

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Technical documents: CoA Datasheet

Product overview

Name

TAT-Gap19

Purity

>95%

Description

Cx43 hemichannel blocker. Active in vivo.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3)

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Biological Data

Biological description

Cx43 hemichannel blocker. Inhibits astroglial Cx43 hemichannels in a dose-dependent manner, without affecting gap junction channels and reduces mitochondrial potassium influx. Also reduces intracellular ROS generation, cell death, inflammation and premature cell senescence.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in water (1 mg/ml)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>95%

Molecular Weight

2703.28

Molecular Formula

C₁₁₉H₂₁₂N₄₆O₂₆

CAS Number

1507930-54-2

PubChem identifier

127021051

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

Source

Synthetic

InChiKey

ALNCFPIRTLVJPY-XELKYWHDNA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for TAT-Gap19

References are publications that support the biological activity of the product

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.
Lissoni A et al (2020) International journal of molecular sciences 21 :
Read more (PubMedID: 33027889)
Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.
Ramadan R et al (2020) Frontiers in pharmacology 11 : 212
Read more (PubMedID: 32210810)
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara V et al (2014) Frontiers in cellular neuroscience 8 : 306
Read more (PubMedID: 25374505)

Cx43 hemichannel blocker. Active in vivo.

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1mg	$200

TAT-Gap19

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for TAT-Gap19

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

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TAT-Gap19

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for TAT-Gap19

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

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Tell us about your publication!

Captcha

About you

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