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TAT-Gap19

(HB9841)
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Product overview

Name TAT-Gap19
Purity >95%
Description Cx43 hemichannel blocker. Active in vivo.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Cx43 hemichannel blocker. Inhibits astroglial Cx43 hemichannels in a dose-dependent manner, without affecting gap junction channels and reduces mitochondrial potassium influx. Also reduces intracellular ROS generation, cell death, inflammation and premature cell senescence.

Solubility & Handling

Solubility overview Soluble in water (1 mg/ml)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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x
More Info

Dilution

x
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x
More Info

Chemical Data

Purity >95%
Molecular Weight 2703.28
Molecular Formula C119H212N46O26
CAS Number 1507930-54-2
PubChem identifier 127021051
SMILES [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O
Source Synthetic
InChiKey ALNCFPIRTLVJPY-XELKYWHDNA-N

References for TAT-Gap19

References are publications that support the biological activity of the product

  • Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

    Lissoni A et al (2020) International journal of molecular sciences 21 :
    Read more (PubMedID: 33027889)

  • Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

    Ramadan R et al (2020) Frontiers in pharmacology 11 : 212
    Read more (PubMedID: 32210810)

  • The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

    Abudara V et al (2014) Frontiers in cellular neuroscience 8 : 306
    Read more (PubMedID: 25374505)

3 Item(s)

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Grouped product items
Order: HB9841
Pack PriceQty
1mg
$207
Cx43 hemichannel blocker. Active in vivo.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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