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Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical structure
Molecular Formula C91 H127 N25 O23 S
Sequence (one letter) VGRPEWWMDYQKRYG
Sequence (three letter) Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly
PubChem identifier 16158367
SMILES CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)NCC(=O)O)N
InChiKey GOEYECACIBFJGZ-NPAGUKBMSA-N
References for BAM (8-22) References are publications that support the biological activity of the product
Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Li et al (2017) Proc Natl Acad Sci U S A. 114(10) : E1996-E2005 BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. Sikand et al (2011) J Neurosci 31(20) : 7563-7 Mas-related G-protein-coupled receptors inhibit pathological pain in mice. Guan et al (2010) Proc Natl Acad Sci U S A. 107(36) : 15933-8
Publications
These publications cite the use of BAM (8-22) purchased from Hello Bio:
Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves McMillan H et al (2021) FASEB J 35(5) : e21492
Product of proenkephalin A. MRGPRs activator.
![BAM (8-22) [412961-36-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb2922_1.png "BAM (8-22) [412961-36-5]")
Understanding purity and quality - a guide for life scientists
