Product overview

Name BAM (8-22)
Biological description

BAM (8-22) is a product of the opioid precursor proenkephalin A. It is a potent activator of Mas-related GPCR (MRGPRs): MRGPRC C11 and hMRGPRX1.

BAM (8-22) does not contain the met-enekphalin motif (unlike BAM-22P) and therefore lacks affinity for opioid receptors.

Active in vivo. Produces itch and nociceptive sensations.

Purity >95%
Description Product of proenkephalin A. MRGPRs activator.
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Molecular Weight 1971.22
Chemical structure BAM (8-22) [412961-36-5] Chemical Structure
Molecular Formula C91H127N25O23S
Sequence (one letter) VGRPEWWMDYQKRYG
Sequence (three letter) Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly
CAS Number 412961-36-5
PubChem identifier 16158367
SMILES CC(C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC4=CNC5=CC=CC=C54)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)NCC(=O)O)N
Protein length 15

References for BAM (8-22)

References are publications that support the biological activity of the product
  • Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.

    Li et al (2017) Proc Natl Acad Sci U S A. 114(10) : E1996-E2005
  • BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release.

    Sikand et al (2011) J Neurosci 31(20) : 7563-7
  • Mas-related G-protein-coupled receptors inhibit pathological pain in mice.

    Guan et al (2010) Proc Natl Acad Sci U S A. 107(36) : 15933-8

3 Item(s)

These publications cite the use of BAM (8-22) purchased from Hello Bio:
  • Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves

    McMillan H et al (2021) FASEB J 35(5) : e21492
    PubMedID: 33788969

1 Item