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SKF 89976A hydrochloride

(HB0976)
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Product overview

Name SKF 89976A hydrochloride
Purity >99%
Description Potent, selective, competitive GAT-1 GABA uptake inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Images

SKF 89976A hydrochloride product vial image | Hello Bio
SKF 89976A hydrochloride product vial image | Hello Bio

SKF 89976A hydrochloride product vial image | Hello Bio

SKF 89976A hydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in water (100mM, gentle warming) or DMSO (100mM)
Storage instructions +4°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Molecular Weight 371.91
Chemical structure SKF 89976A hydrochloride [85375-15-1] Chemical Structure
Molecular Formula C22H25NO2.HCl
CAS Number 85375-15-1
PubChem identifier 6917797
SMILES Cl[H].OC(=O)C1CCCN(CC\C=C(\C2=CC=CC=C2)C2=CC=CC=C2)C1
InChiKey SNGGBKYQZVAQKA-UHFFFAOYSA-N

References for SKF 89976A hydrochloride

References are publications that support the biological activity of the product

  • Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.

    Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
    Read more (PubMedID: 16150932)

  • Orally active and potent inhibitors of gamma-aminobutyric acid uptake.

    Ali FE et al (1985) J Med Chem 28(5) : 653-60.
    Read more (PubMedID: 2985785)

  • Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and Ro 5-2807 in amygdaloid kindled rats.

    Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.
    Read more (PubMedID: 4033806)

3 Item(s)

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Grouped product items
Order: HB0976
Pack PriceQty
10mg
$165
50mg
$819
Potent, selective, competitive GAT-1 GABA uptake inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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