Product overview

Name SKF 89976A hydrochloride
Description Potent, selective, competitive GAT-1 GABA uptake inhibitor
Purity >99%
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Biological Data

Biological description Potent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM, gentle warming) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
Molecular Weight 371.91
Chemical structure SKF 89976A hydrochloride  [85375-15-1] Chemical Structure
Molecular Formula C22H25NO2.HCl
CAS Number 85375-15-1
PubChem identifier 6917797
SMILES Cl[H].OC(=O)C1CCCN(CC\C=C(\C2=CC=CC=C2)C2=CC=CC=C2)C1
InChiKey SNGGBKYQZVAQKA-UHFFFAOYSA-N

References for SKF 89976A hydrochloride

References are publications that support the biological activity of the product
  • Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.

    Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.
  • Orally active and potent inhibitors of gamma-aminobutyric acid uptake.

    Ali FE et al (1985) J Med Chem 28(5) : 653-60.
  • Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and Ro 5-2807 in amygdaloid kindled rats.

    Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.