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Biological Data Biological description Guanosine analog with broad spectrum antiviral activity (agonist DNA and RNA viruses). Shows antiviral activity against a number of viruses including SARS-CoV.
Also shows anti-cancer activity.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in water (100mM) and DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name 1-β-D -Ribofuranosyl-1H -1,2,4-triazole-3-carboxamide
Chemical structure
Molecular Formula C8 H12 N4 O5
SMILES O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O
InChi InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
InChiKey IWUCXVSUMQZMFG-AFCXAGJDSA-N
References for Ribavirin References are publications that support the biological activity of the product
Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study Elfiky AA (2020) Life Sci 253 : 117592 Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Tan EL et al (2004) Emerg Infect Dis 10(4) : 581-6 Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap Kentsis A et al (2004) Proc Natl Acad Sci U S A 101(52) : 18105-10
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Guanosine analog with antiviral activity