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Solubility & Handling Storage instructions -20°C
Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a solution (0.5mg/ml) in phosphate buffer (20mM, pH 8.0) and NaCl (0.5M)
References for Recombinant human proBDNF protein References are publications that support the biological activity of the product
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures Riffault B et al (2018) Cereb Cortex 28(2) : 510-527 proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing Fleitas C et al (2018) Mol Brain 11(1) : 68 Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing Yang M et al (2011) J Biol Chem 286(18) : 16272-84
