Recombinant human Persephin / PSPN protein

(HB9314)
Technical documents: CoA Datasheet

Product overview

Name Recombinant human Persephin / PSPN protein
Alternative names Recombinant Human Persephin, Persephin, PSP, PSPN.
Purity >95%
Description Recombinant human Persephin (PSPN) protein
Write Your Own Review
You're reviewing:Recombinant human Persephin / PSPN protein
Rate this item:

Biological Data

Application notes Fully biologically active when compared to standard. ED50 = <10ng/ml (determined by a cell proliferation assay using human TT medullary thyroid cancer cells), corresponding to a specific activity of > 1.0 x 100,000 IU/mg

Solubility & Handling

Storage instructions -20°C
Solubility overview To make a stock solution, reconstitute in 4mM HCl at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >95%
UniProt ID O60542
Molecular Weight 20.5
Source E. Coli.
Structure image  Chemical Structure
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in PBS (pH 7.4)

References for Recombinant human Persephin / PSPN protein

References are publications that support the biological activity of the product
  • Persephin signaling through GFRalpha1: the potential for the treatment of Parkinson's disease

    Sidorova YA et al (2010) Mol Cell Neurosci 44(3) : 223-32
  • Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease

    Akerud P et al (2002) Mol Cell Neurosci 21(2) : 205-22
  • Persephin, a novel neurotrophic factor related to GDNF and neurturin

    Milbrandt J et al (1998) Neuron 20(2) : 245-53

3 Item(s)