Recombinant human Neurturin / NRTN protein

(HB9447)
Technical documents: Datasheet

Product overview

Name Recombinant human Neurturin / NRTN protein
Alternative names Recombinant Human Neurturin, Neurturin.
Purity >96%
Description GDNF-related trophic factor
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Biological Data

Application notes Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA.

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 0.5mg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >96%
UniProt ID Q99748
Source E. Coli.
Structure image  Chemical Structure
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2 μm filtered solution containing sodium citrate (30 mM, pH 4.2), NaCl (0.4M) and 0.02 % Tween-20

References for Recombinant human Neurturin / NRTN protein

References are publications that support the biological activity of the product
  • Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis

    Sakai K et al (2017) Pain 158(11) : 2196-2202
  • Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in periphera

    Widenfalk J et al (1997) J Neurosci 17(21) : 8506-19
  • Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

    Creedon DJ et al (1997) Proc Natl Acad Sci U S A 94(13) : 7018-23

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