Product overview
Name | Recombinant human Neurturin / NRTN protein |
Description | GDNF-related trophic factor |
Alternative names | Recombinant Human Neurturin, Neurturin. |
Purity | >96% |
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Biological Data
Application notes | Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA. |
Solubility & Handling
Solubility overview | To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 0.5mg/ml, which can then be diluted to make a working solution |
Handling |
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Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
Source | E. Coli. |
Appearance | White lyophilized powder (sterile filtered & freeze-dried) |
Formulation | Lyophilized from a 0.2 μm filtered solution containing sodium citrate (30 mM, pH 4.2), NaCl (0.4M) and 0.02 % Tween-20 |
References for Recombinant human Neurturin / NRTN protein
References are publications that support the biological activity of the product
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Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis
Sakai K et al (2017) Pain 158(11) : 2196-2202 -
Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in periphera
Widenfalk J et al (1997) J Neurosci 17(21) : 8506-19 -
Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons
Creedon DJ et al (1997) Proc Natl Acad Sci U S A 94(13) : 7018-23