Recombinant human Neurturin / NRTN protein

(HB9447)
Technical documents: Datasheet

Product overview

Name Recombinant human Neurturin / NRTN protein
Description GDNF-related trophic factor
Alternative names Recombinant Human Neurturin, Neurturin.
Purity >96%
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Biological Data

Application notes Fully biologically active when compared to standard. The biologically active as determined by its binding ability in a functional ELISA.

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 0.5mg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Source E. Coli.
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2 μm filtered solution containing sodium citrate (30 mM, pH 4.2), NaCl (0.4M) and 0.02 % Tween-20

References for Recombinant human Neurturin / NRTN protein

References are publications that support the biological activity of the product
  • Role of neurturin in spontaneous itch and increased nonpeptidergic intraepidermal fiber density in a mouse model of psoriasis

    Sakai K et al (2017) Pain 158(11) : 2196-2202
  • Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in periphera

    Widenfalk J et al (1997) J Neurosci 17(21) : 8506-19
  • Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

    Creedon DJ et al (1997) Proc Natl Acad Sci U S A 94(13) : 7018-23