Recombinant human Neuropilin-1 / NRP1 protein

(HB7292)
Technical documents: Datasheet

Product overview

Name Recombinant human Neuropilin-1 / NRP1 protein
Biological description

Neuropilin-1 takes part in cell survival, angiogenesis, invasion, migration, and axon guidance.

Alternative names NRP1 Human, Neuropilin-1 isoform a, NRP1, BDCA4, CD304, NP1, NRP, VEGF165R, Vascular endothelial cell growth factor 165 receptor.
Purity >90%
Description

Membrane-bound coreceptor

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Biological Data

Application notes Recombinant human Neuropilin-1 / NRP1 protein (produced in Sf9 Baculovirus cells) is a single, glycosylated polypeptide chain containing 843 amino acids (22-856a.a.) and has a molecular mass of 94.8kDa. The molecular size will appear at approximately 100-150kDa by SDS-PAGE. This protein is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Solubility & Handling

Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >90%
UniProt ID O14789
Source Sf9, Baculovirus cells.
Structure image  Chemical Structure
Appearance Colourless solution (sterile filtered)
Formulation Solution (0.25mg/ml) containing PBS (pH7.4) and 20% glycerol.

References for Recombinant human Neuropilin-1 / NRP1 protein

References are publications that support the biological activity of the product
  • Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

    Roth L et al (2016) Sci Signal 9(425) : ra42
  • Neuropilin 1: function and therapeutic potential in cancer

    Chaudhary B et al (2014) Cancer Immunol Immunother 63(2) : 81-99
  • Neuropilin-1 expression in cancer and development

    Jubb AM et al (2012) J Pathol 226(1) : 50-60

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