Recombinant human Neurogranin / NRGN protein

(HB8383)
Technical documents: Datasheet

Product overview

Name Recombinant human Neurogranin / NRGN protein
Biological description

Postsynaptic protein that is a cerebrospinal fluid (CSF) biomarker for Alzheimer's disease.

Alternative names Recombinant Human Neurogranin?, hng, RC3, Neurogranin, Ng, NRGN.
Purity >90%
Description Postsynaptic protein
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Solubility & Handling

Storage instructions +4°C 2-4 weeks (long term see website) 
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >90%
UniProt ID Q92686
Concentration 0.5mg/mL
Molecular Weight 10
Sequence (one letter) MGSSHHHHHH SSGLVPRGSH MGSMDCCTEN ACSKPDDDIL DIPLDDPGAN AAAAKIQASF RGHMARKKIK SGERGRKGPG PGGPGGAGVA RGGAGGGPSG D
Source E. Coli.
Structure image  Chemical Structure
Appearance Colourless solution (sterile filtered)
Formulation Solution (0.5mg/ml) containing Tris-HCl buffer (20mM, pH7.0), 30% glycerol PMSF (0.1mM) and EDTA (1mM)

References for Recombinant human Neurogranin / NRGN protein

References are publications that support the biological activity of the product
  • The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease

    Kvartsberg H et al (2019) Acta Neuropathol 137(1) : 89-102
  • Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

    Casaletto KB et al (2017) Neurology 89(17) : 1782-1788
  • Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease

    Thorsell A et al (2010) Brain Res 1362 : 13-22

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