Recombinant human Neurogranin / NRGN protein

(HB8383)
Technical documents: Datasheet

Product overview

Name Recombinant human Neurogranin / NRGN protein
Biological description

Postsynaptic protein that is a cerebrospinal fluid (CSF) biomarker for Alzheimer's disease.

Alternative names Recombinant Human Neurogranin?, hng, RC3, Neurogranin, Ng, NRGN.
Purity >90%
Description Postsynaptic protein
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Solubility & Handling

Storage instructions +4°C 2-4 weeks (long term see website) 
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >90%
Concentration 0.5mg/mL
Molecular Weight 10
Sequence (one letter) MGSSHHHHHH SSGLVPRGSH MGSMDCCTEN ACSKPDDDIL DIPLDDPGAN AAAAKIQASF RGHMARKKIK SGERGRKGPG PGGPGGAGVA RGGAGGGPSG D
Source E. Coli.
Appearance Colourless solution (sterile filtered)
Formulation Solution (0.5mg/ml) containing Tris-HCl buffer (20mM, pH7.0), 30% glycerol PMSF (0.1mM) and EDTA (1mM)

References for Recombinant human Neurogranin / NRGN protein

References are publications that support the biological activity of the product
  • The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's disease

    Kvartsberg H et al (2019) Acta Neuropathol 137(1) : 89-102
  • Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

    Casaletto KB et al (2017) Neurology 89(17) : 1782-1788
  • Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease

    Thorsell A et al (2010) Brain Res 1362 : 13-22

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