Recombinant human Neuritin-1 / NRN1 protein

(HB7631)
Technical documents: Datasheet

Product overview

Name Recombinant human Neuritin-1 / NRN1 protein
Biological description

Neurotrophic factor expressed in response to induction of neuronal activity by NGF, BDNF, NT3 and other neural stimulators.

Functions as a molecular mediator of neurite outgrowth, neuronal survival, and synaptic maturation.

Alternative names Recombinant Human Neuritin-1, Neuritin 1, NRN1, NRN, dJ380B8.2, Neuritin.
Purity >95%
Description Neurotrophic factor
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Biological Data

Application notes The ED50 = <25ng/ml (determined by a cell proliferation assay using rat C6 cells), corresponding to a specific activity of >4.0 x 104 IU/mg.

Solubility & Handling

Solubility overview To make a stock solution, reconstitute the lyophilized NRN1 in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
UniProt ID Q9NPD7
Source E. Coli.
Structure image  Chemical Structure
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered concentrated solution in PBS (pH 7.4)

References for Recombinant human Neuritin-1 / NRN1 protein

References are publications that support the biological activity of the product
  • Neuritin 1 promotes neuronal migration

    Zito A et al (2014) Brain Struct Funct 219(1) : 105-18
  • Neuritin, a neurotrophic factor in nervous system physiology

    Zhou S et al (2014) Curr Med Chem 21(10) : 1212-9
  • Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia

    Chandler D et al (2010) Am J Med Genet B Neuropsychiatr Genet 153B(2) : 428-437

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