Recombinant human Neuregulin-4 / NRG4 protein

(HB9996)
Technical documents: Datasheet

Product overview

Name Recombinant human Neuregulin-4 / NRG4 protein
Biological description

Member of the EGF family of proteins which is highly and preferentially expressed in healthy adipocytes.

Recently shown to be a novel regulator of dendritic growth and arborization and spine formation in the striatum.

Alternative names Recombinant Human Neuregulin-4, Neuregulin 4, HRG4, Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG-4.
Purity >90%
Description Growth factor which is part of the neuregulin family
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Solubility & Handling

Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >90%
UniProt ID Q8WWG1
Source E. Coli.
Structure image  Chemical Structure
Appearance Clear solution (sterile filtered)
Formulation Solution (0.25mg/ml) containing Tris-HCl(20mM, pH8.0), 30% glycerol, NaCl (150mM) and DTT (1mM)

References for Recombinant human Neuregulin-4 / NRG4 protein

References are publications that support the biological activity of the product
  • Neuregulin-4 Is Required for the Growth and Elaboration of Striatal Medium Spiny Neuron Dendrites

    Paramo B et al (2019) J Neuropathol Exp Neurol : 0
  • Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature

    Nugroho DB et al (2018) Biochem Biophys Res Commun 503(1) : 378-384
  • Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo

    Bernard JK et al (2012) J Biol Chem 287(47) : 39850-8

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