Recombinant human Neuregulin-4 / NRG4 protein

(HB9996)
Technical documents: Datasheet

Product overview

Name Recombinant human Neuregulin-4 / NRG4 protein
Biological description

Member of the EGF family of proteins which is highly and preferentially expressed in healthy adipocytes.

Recently shown to be a novel regulator of dendritic growth and arborization and spine formation in the striatum.

Alternative names Recombinant Human Neuregulin-4, Neuregulin 4, HRG4, Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG-4.
Purity >90%
Description Growth factor which is part of the neuregulin family
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Solubility & Handling

Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • For long term storage, a carrier protein (0.1% HSA or BSA) should be added to stock solutions. Solutions should be aliquoted into tightly sealed vials for storage at -20°C. Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >90%
Source E. Coli.
Appearance Clear solution (sterile filtered)
Formulation Solution (0.25mg/ml) containing Tris-HCl(20mM, pH8.0), 30% glycerol, NaCl (150mM) and DTT (1mM)

References for Recombinant human Neuregulin-4 / NRG4 protein

References are publications that support the biological activity of the product
  • Neuregulin-4 Is Required for the Growth and Elaboration of Striatal Medium Spiny Neuron Dendrites

    Paramo B et al (2019) J Neuropathol Exp Neurol : 0
  • Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature

    Nugroho DB et al (2018) Biochem Biophys Res Commun 503(1) : 378-384
  • Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo

    Bernard JK et al (2012) J Biol Chem 287(47) : 39850-8

3 Item(s)