Recombinant human Neuregulin-1 Alpha / NRG1A protein

(HB4985)
Technical documents: Datasheet

Product overview

Name Recombinant human Neuregulin-1 Alpha / NRG1A protein
Alternative names NRG1 A Human, Neuregulin-1, Heregulin Alpha, NRG1-A, NRG1 A.
Purity >97%
Description Human Recombinant Neuregulin-1/Heregulin Alpha (EGF Domain) protein
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Biological Data

Application notes The ED50 = ≤40ng/ml (determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells), corresponding to a specific activity of > 2.5x104 units/mg

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • Freeze-thaw cycles should be prevented.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >97%
Source E. Coli.
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in 20mM PB (pH 6.0) and 150mM NaCl

References for Recombinant human Neuregulin-1 Alpha / NRG1A protein

References are publications that support the biological activity of the product
  • Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins

    Bian Y et al (2009) Am J Physiol Heart Circ Physiol 297(6) : H1974-83
  • Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

    Mei L et al (2008) Nat Rev Neurosci 9(6) : 437-52
  • Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology

    Harrison PJ et al (2006) Biol Psychiatry 60(2) : 132-40

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