Recombinant human Neuregulin-1 Alpha / NRG1A protein

(HB4985)

Certificate of Analysis

Latest Certificate of Analysis

Download the latest CoA for this product:

Download CoA

Download Batch-Specific CoA

To download the CoA for a batch, enter the batch ID below:

Technical documents: CoA Datasheet

Product overview

Name Recombinant human Neuregulin-1 Alpha / NRG1A protein
Alternative names NRG1 A Human, Neuregulin-1, Heregulin Alpha, NRG1-A, NRG1 A.
Purity >97%
Description Human Recombinant Neuregulin-1/Heregulin Alpha (EGF Domain) protein
Write Your Own Review
You're reviewing:Recombinant human Neuregulin-1 Alpha / NRG1A protein
Rate this item:

Biological Data

Application notes The ED50 = ≤40ng/ml (determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells), corresponding to a specific activity of > 2.5x104 units/mg

Solubility & Handling

Solubility overview To make a stock solution, reconstitute in sterile 18MΩcm water at a concentration > 100μg/ml, which can then be diluted to make a working solution
Handling
  • Solutions should be made in sterile deionized water (not less than 100 µg/ml). This solution can then be further diluted with other aqueous solutions.
  • Following reconstitution, solutions may be stored at 4°C and are useable for around 2-7 days and for future use store at -18°C.
  • Freeze-thaw cycles should be prevented.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >97%
UniProt ID A0A494BZT4
Source E. Coli.
Structure image  Chemical Structure
Appearance White lyophilized powder (sterile filtered & freeze-dried)
Formulation Lyophilized from a 0.2μm filtered solution in 20mM PB (pH 6.0) and 150mM NaCl

References for Recombinant human Neuregulin-1 Alpha / NRG1A protein

References are publications that support the biological activity of the product
  • Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins

    Bian Y et al (2009) Am J Physiol Heart Circ Physiol 297(6) : H1974-83
  • Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

    Mei L et al (2008) Nat Rev Neurosci 9(6) : 437-52
  • Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology

    Harrison PJ et al (2006) Biol Psychiatry 60(2) : 132-40

3 Item(s)