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PLX5622

(HB17582)
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Product overview

Name PLX5622
Alternative names PLX5622
Purity >98%
Description

Highly selective, potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3)
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Biological Data

Biological description

Highly selective, brain penetrant, potent CSF-1R inhibitor (Ki = 5.9 nM). Allows specific and extended brain microglial elimination, preceding and during pathology development.

Solubility & Handling

Solubility overview Soluble in DMSO (50 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 6-Fluoro-N-((5-fluoro-2-methoxypyridin-3-yl)methyl)-5-((5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine
Molecular Weight 395.41
Molecular Formula C22H19F2N5O
CAS Number 1303420-67-8
PubChem identifier 52936034
SMILES CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1
InChi InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
InChiKey NSMOZFXKTHCPTQ-UHFFFAOYSA-N

References for PLX5622

References are publications that support the biological activity of the product

  • Putting PLX5622 into perspective: microglia in central nervous system viral infection.

    Spiteri AG et al (2023) Neural regeneration research 18 : 1269-1270
    Read more (PubMedID: 36453408)

  • Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.

    Mein N et al (2023) Journal of neuroinflammation 20 : 289
    Read more (PubMedID: 38041192)

  • Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour.

    Rosin JM et al (2018) Brain, behavior, and immunity 73 : 682-697
    Read more (PubMedID: 30056204)

3 Item(s)

Grouped product items
Order: HB17582
Pack PriceQty
5mg
$98
25mg
$294

Highly selective, potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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