Highly selective, brain penetrant, potent CSF-1R inhibitor (Ki = 5.9 nM). Allows specific and extended brain microglial elimination, preceding and during pathology development.
Solubility & Handling
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour.
Rosin JM et al (2018) Brain, behavior, and immunity 73 : 682-697
Understanding purity and quality - a guide for life scientists