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Oseltamivir phosphate

(HB7776)
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Product overview

Name Oseltamivir phosphate
Alternative names GS-4104; Ro 64-0796/002
Purity >98%
Description Antiviral compound. Influenza viral neuraminidase inhibitor.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

Oseltamivir phosphate is an influenza viral neuraminidase inhibitor which once hydrolyzed to its active metabolite can competitively inhibit viral neuraminidase (IC50 = 0.1-4.9nM for influenza neuraminidases A and B).

Recently studied as part of COVID-19 compound repurposing.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (75 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoric acid
Molecular Weight 410.4
Molecular Formula C16H31N2O8P
CAS Number 204255-11-8
PubChem identifier 78000
SMILES CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O
InChi InChI=1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1
InChiKey PGZUMBJQJWIWGJ-ONAKXNSWSA-N
MDL number MFCD08059548

References for Oseltamivir phosphate

References are publications that support the biological activity of the product

  • Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19

    Muralidharan N et al (2020) J Biomol Struct Dyn : 43983
    Read more (PubMedID: 32248766)

  • Human specific loss of olfactory receptor genes

    Gilad Y et al (2003) Proc Natl Acad Sci U S A 100(6) : 3324-7
    Read more (PubMedID: 12612342)

  • Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor

    Sidwell RW et al (1998) Antiviral Res 37(2) : 107-20
    Read more (PubMedID: 9588843)

3 Item(s)

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Grouped product items
Order: HB7776
Pack PriceQty
100mg
$42
500mg
$205
Antiviral compound. Influenza viral neuraminidase inhibitor.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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