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Nociceptin

(HB2424)
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Technical documents: SDS CoA Datasheet
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Product overview

Name Nociceptin
Biological description

Nociceptin is a 17-amino acid neuropeptide which is the endogenous ligand for the nociceptin (NOP) receptor (previously known as ORL1). Nociceptin shows no activity at the classical μ, δ or κ opioid receptors.


The neuropeptide is active in vivo and is involved in a variety of physiological processes. For example, it has been shown to be involved in pain, anxiety, depression, obesity, addiction, hyperphagia, Parkinson’s ,cognition, cardiovascular, inflammatory and learning and memory.

Alternative names N/OFQ, Orphanin FQ,
Purity >95%
Description Endogenous NOP agonist. Involved in a variety of physiological processes.
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Images

Nociceptin product vial image | Hello Bio
Nociceptin product vial image | Hello Bio

Nociceptin product vial image | Hello Bio

Nociceptin product vial image | Hello Bio

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >95%
Chemical name FGGFTGARKSARKLANQ
Molecular Weight 1809.07
Chemical structure Nociceptin [170713-75-4] Chemical Structure
Molecular Formula C79H129N27O22
Sequence (one letter) FGGFTGARKSARKLANQ
Sequence (three letter) Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln
CAS Number 170713-75-4
PubChem identifier 16131448
SMILES C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)N)O
InChiKey PULGYDLMFSFVBL-SMFNREODSA-N
Protein length 17

References for Nociceptin

References are publications that support the biological activity of the product

  • Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.

    Pacifico et al (2017) Sci Rep. 6 : 7:45817
    Read more (PubMedID: 28383520)

  • Evidence for nociceptin/orphanin FQ (NOP) but not µ (MOP), δ (DOP) or κ (KOP) opioid receptor mRNA in whole human blood.

    ASl-Hashimi et al (2016) Br J Anaesth 116(3) : 423-9
    Read more (PubMedID: 26865135)

  • The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

    Witkin et al (2014) Pharmacol Ther 141(3) : 283-99
    Read more (PubMedID: 24189487)

  • The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation.

    Bongsebandhu-phubhakdi et al (2007) J Neurosci 27(18) : 4850-8
    Read more (PubMedID: 17475793)

4 Item(s)

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Order: HB2424
Pack PriceQty
1mg
$113
5mg
$312
Endogenous NOP agonist. Involved in a variety of physiological processes.
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