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Biological Data

Biological description Potent, selective and ATP-competitive mTOR inhibitor (IC50 = 2.1 nM and EC50 value = 250 pM for inhibition of cellular mTOR activity). Shows 800-fold selectivity over PI3K and >100-fold selectivity over ~400 other protein kinases. Shows potent antiproliferative activity. Causes apoptosis and autophagy and induces G0/G1 cell cycle arrest.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 9-(6-Amino-3-pyridinyl)-1-[3-(trifl uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H) -one
Molecular Weight 432.4
Molecular Formula C24H15F3N4O
CAS Number 1223001-51-1
PubChem identifier 51358113
SMILES O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12
InChiKey GUXXEUUYCAYESJ-UHFFFAOYSA-N

References for Torin 2

References are publications that support the biological activity of the product
  • Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.

    Simioni et al (2014) Oncotarget 5(20) : 10034-47
  • Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

    Liu et al (2013) Cancer Res 73(8) : 2574-86
  • Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

    Liu et al (2011) J Med Chem 54(5) : 1473-80

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