Product overview

Name LL-37 (human)
Biological description

Cell permeable antimicrobial host defense peptide derived from the C-terminal of human cathelicidin. Acts on host cells to exert immunomodulatory functions as part of its role in host defense and immunity. Mediates chemotaxis, promotes wound healing, angiogenesis and induces tumorigenic effects in various cancers.

Recently shown to reduce SARS-CoV-2 infection by blocking the S1 spike protein RBD (receptor binding domain) (Kd = 11.2 nM). LL-37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 µg/mL) in vitro and in vivo and also binds to ACE2 (Kd = 25.5 nM) to cloak the LBD (ligand binding domain) to decrease S1 adherence and protect cells against pseudovirion infection in vitro.

Displays antimicrobial, antibacterial, antitumour, anti-cancer and antiviral activities.


Control Peptide also available.

Alternative names Ropocamptide, hCAP 18, Cathelicidin
Purity >95%

Antimicrobial peptide. Reduces SARS-Cov2 infection.

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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in aqueous buffer (1 mg/ml), and in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Molecular Weight 4493.3
Molecular Formula C205H340N60O53
Sequence (three letter) H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
CAS Number 154947-66-7
PubChem identifier 16198951

References for LL-37 (human)

References are publications that support the biological activity of the product
  • Human Cathelicidin Inhibits SARS-CoV-2 Infection: Killing Two Birds with One Stone

    Wang C et al (2021) ACS Infect Dis 7(6) : 1545-1554
  • Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties

    Seil et al (2010) Pharmaceuticals (Basel). 3(11) : 3435-3460

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