Cell permeable antimicrobial host defense peptide derived from the C-terminal of human cathelicidin. Acts on host cells to exert immunomodulatory functions as part of its role in host defense and immunity. Mediates chemotaxis, promotes wound healing, angiogenesis and induces tumorigenic effects in various cancers.
Recently shown to reduce SARS-CoV-2 infection by blocking the S1 spike protein RBD (receptor binding domain) (Kd = 11.2 nM). LL-37 inhibits SARS-CoV-2 pseudovirion infection (IC50 = 4.74 µg/mL) in vitro and in vivo and also binds to ACE2 (Kd = 25.5 nM) to cloak the LBD (ligand binding domain) to decrease S1 adherence and protect cells against pseudovirion infection in vitro.
Displays antimicrobial, antibacterial, antitumour, anti-cancer and antiviral activities.