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Only identified mouse cathelicidin and
LL 37 (human) homolog. Displays chemotactic effects (e.g. for monocytes, neutrophils and macrophages) and enhances the adaptive immune response. Down-regulates LPA-induced innate immune responses and shows angiogenic, antimicrobial and antiviral activity.
Alternative names Mouse calethicidin related antimicrobial peptide Solubility & Handling
Storage instructions -20°C
Soluble in aqueous buffer
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use Chemical Data
178H 302N 50O 46
Sequence (one letter) GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ
Sequence (three letter) H-Gly-Leu-Leu-Arg-Lys-Gly-Gly-Glu-Lys-Ile-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-Gln-Pro-Glu-Gln-OH References for mCRAMP (mouse)
References are publications that support the biological activity of the product
The Antimicrobial Cathelicidin CRAMP Augments Platelet Activation during Psoriasis in Mice Salamah MF et al (2020) Biomolecules 10(9) : 0 Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics Gupta K et al (2015) Antibiotics (Basel) 4(3) : 358-78 The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway Singh D et al (2013) J Biol Chem 288(12) : 8258-8268 Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens Iimura M et al (2005) J Immunol 174(8) : 4901-7