Product overview
Name | Linezolid |
Alternative names | PNU 100766, U 100766 |
Purity | >98% |
Description | Inhibits protein synthesis in gram-positive bacteria. Antibiotic. |
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Biological Data
Biological description | Antibiotic which inhibits protein synthesis in gram-positive bacteria. Shows antibacterial activity against various multidrug-resistant gram-positive microbes. Identified as targeting human host cell proteins that interact with SARS-CoV-2 so investigated as part of COVID-19 compound repurposing. |
Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in DMSO (100mM) and ethanol (25mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
Purity | >98% |
Chemical name | N-[[(5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide |
Molecular Weight | 337.35 |
Chemical structure | |
Molecular Formula | C16H20FN3O4 |
CAS Number | 165800-03-3 |
PubChem identifier | 441401 |
SMILES | FC1=CC(N3C[C@H](CNC(C)=O)OC3=O)=CC=C1N2CCOCC2 |
InChi | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
InChiKey | TYZROVQLWOKYKF-ZDUSSCGKSA-N |
MDL number | MFCD00937825 |
Related areas
Technical guides
References for Linezolid
References are publications that support the biological activity of the product
-
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Krogan et al (2020) Nature 7816 : 459-468 -
Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections
Manninen (2008) J Med Chem 51(7) : 1981-90 -
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections
Zurenko et al (1996) J Med Chem 39(3) : 673-9
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Inhibits protein synthesis in gram-positive bacteria. Antibiotic.
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