Product overview

Name Gemcitabine hydrochloride
Purity >98%
Description DNA synthesis and repair inhibitor
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Biological Data

Biological description

Nucleoside analog which resembles Deoxycytidine and inhibits DNA synthesis and repair.

Shows anticancer and antitumor activity.

Also inhibits MERS-CoV and SARS-CoV in vitro (EC50 values are 1.2 and 4.9 µM, respectively).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (100 mM), and in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >98%
Chemical name (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Molecular Weight 299.66
Chemical structure Gemcitabine hydrochloride [122111-03-9] Chemical Structure
Molecular Formula C9H11F2N3O4.HCl
CAS Number 122111-03-9
PubChem identifier 69101485
SMILES OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C(N=C(N)C=C2)=O)O1.Cl
InChi InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
MDL number MFCD01735988

References for Gemcitabine hydrochloride

References are publications that support the biological activity of the product
  • Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

    Dyall et al (2014) Antimicrob Agents Chemother 58(8) : 4885-93
  • The role of gemcitabine in the treatment of other tumours

    Carmichael (1998) BR J Cancer. 78 : 21-5
  • Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism

    Heinemann et al (1995) Semin Oncol. 22 : 11-8

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