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Biological Data
| Biological description | Nucleoside analog which resembles Deoxycytidine and inhibits DNA synthesis and repair.
Shows anticancer and antitumor activity.
Also inhibits MERS-CoV and SARS-CoV in vitro (EC50 values are 1.2 and 4.9 µM, respectively). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in water (100 mM), and in DMSO (20 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride |
| Chemical structure | ![Gemcitabine hydrochloride [122111-03-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Gemcitabine hydrochloride [122111-03-9]") |
| Molecular Formula | C9H11F2N3O4.HCl |
| PubChem identifier | 69101485 |
| SMILES | OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C(N=C(N)C=C2)=O)O1.Cl |
| InChi | InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1 |
| InChiKey | OKKDEIYWILRZIA-OSZBKLCCSA-N |
References for Gemcitabine hydrochloride
References are publications that support the biological activity of the product
-
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
Dyall et al (2014) Antimicrob Agents Chemother 58(8) : 4885-93 -
The role of gemcitabine in the treatment of other tumours
Carmichael (1998) BR J Cancer. 78 : 21-5 -
Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism
Heinemann et al (1995) Semin Oncol. 22 : 11-8
DNA synthesis and repair inhibitor
![Gemcitabine hydrochloride [122111-03-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4199_1.png "Gemcitabine hydrochloride [122111-03-9]")
Understanding purity and quality - a guide for life scientists
