Selective FZD7 (Frizzled 7 receptor) antagonist which binds to the FZD7 extracellular cysteine rich domain (CRD) to alter its conformation and lipid-binding groove architecture. Inhibits Wnt–β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50 = 100 nM) and blocks WNT3A-mediated β-catenin stabilization in mouse L cells (IC50 = 50 nM). Impairs Wnt signaling in cultured cells and disrupts stem cell function in intestinal organoids.
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Understanding purity and quality - a guide for life scientists
