Selective FZD7 (Frizzled 7 receptor) antagonist which binds to the FZD7 extracellular cysteine rich domain (CRD) to alter its conformation and lipid-binding groove architecture. Inhibits Wnt–β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50 = 100 nM) and blocks WNT3A-mediated β-catenin stabilization in mouse L cells (IC50 = 50 nM). Impairs Wnt signaling in cultured cells and disrupts stem cell function in intestinal organoids.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Understanding purity and quality - a guide for life scientists
