Product overview
| Name | Flumazenil |
| Description | GABAA receptor antagonist |
| Alternative names | Ro 15-1788 |
| Purity | >99% |
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Biological Data
| Biological description | GABAA receptor antagonist, non-selective for α1, α2, α3 or α5 subunits. Binds at the benzodiazepine site. Used as a reversal agent for benzodiazepines. Reverses tolerance to benzodiazepines and restores the neuroprotective actions of diazepam in ischemia models. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in DMSO (25mM, gentle warming) or ethanol (5mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 8-Fluoro-5,6-dihydro-5-methyl-6-oxo -4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester |
| Molecular Weight | 303.29 |
| Chemical structure | ![Flumazenil [78755-81-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0915.png "Flumazenil [78755-81-4]") |
| Molecular Formula | C15H14FN3O3 |
| CAS Number | 78755-81-4 |
| PubChem identifier | 3373 |
| SMILES | CCOC(=O)C1=C2CN(C)C(=O)C3=CC(F)=CC=C3N2C=N1 |
| InChiKey | OFBIFZUFASYYRE-UHFFFAOYSA-N |
References for Flumazenil
References are publications that support the biological activity of the product
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Rapid and reliable sedation induced by diazepam and antagonized by flumazenil in zebra finches (Taeniopygia guttata).
Prather JF (2012) J Avian Med Surg 26(2) : 76-84. -
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Iwata M et al (2012) Br J Anaesth 109(6) : 935-42. -
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.
Atack JR et al (1999) Neuropsychopharmacology 20(3) : 255-62.
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