Product overview

Name Flumazenil
Description GABAA receptor antagonist
Alternative names Ro 15-1788
Purity >99%
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Biological Data

Biological description GABAA receptor antagonist, non-selective for α1, α2, α3 or α5 subunits. Binds at the benzodiazepine site. Used as a reversal agent for benzodiazepines. Reverses tolerance to benzodiazepines and restores the neuroprotective actions of diazepam in ischemia models.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (25mM, gentle warming) or ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 8-Fluoro-5,6-dihydro-5-methyl-6-oxo -4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Molecular Weight 303.29
Chemical structure Flumazenil  [78755-81-4] Chemical Structure
Molecular Formula C15H14FN3O3
CAS Number 78755-81-4
PubChem identifier 3373
SMILES CCOC(=O)C1=C2CN(C)C(=O)C3=CC(F)=CC=C3N2C=N1
InChiKey OFBIFZUFASYYRE-UHFFFAOYSA-N

References for Flumazenil

References are publications that support the biological activity of the product
  • Rapid and reliable sedation induced by diazepam and antagonized by flumazenil in zebra finches (Taeniopygia guttata).

    Prather JF (2012) J Avian Med Surg 26(2) : 76-84.
  • Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.

    Iwata M et al (2012) Br J Anaesth 109(6) : 935-42.
  • Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

    Atack JR et al (1999) Neuropsychopharmacology 20(3) : 255-62.