GABAA receptor antagonist, non-selective for α1, α2, α3 or α5 subunits. Binds at the benzodiazepine site. Used as a reversal agent for benzodiazepines. Reverses tolerance to benzodiazepines and restores the neuroprotective actions of diazepam in ischemia models.
This is a research use only product, exclusively for biomedical research use at verified research organizations. It is not intended for human or veterinary use.
Solubility & Handling
Solubility overview
Soluble in DMSO (25mM, gentle warming) or ethanol (5mM)
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.
Atack JR et al (1999) Neuropsychopharmacology 20(3) : 255-62.
![Flumazenil [78755-81-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0915.png "Flumazenil [78755-81-4]")
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