Product overview

Name FGIN-1-27
Description Potent, selective MDR receptor agonist
Biological description Potent and selective mitochondrial diazepam binding inhibitor receptor (MDR) agonist, also known as peripheral benzodiazepine receptors. Increase Leydig cell steroid and neurosteroid production. Indirectly modulates GABAA receptors by increasing neurosteroids. Shows anti-convulsant actions. Blood-brain barrier permeable.
Purity >98%
Write Your Own Review
You're reviewing:FGIN-1-27
Rate this item:

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Molecular Weight 436.61
Chemical structure Product image
Molecular Formula C28H37FN2O
CAS Number 142720-24-9
PubChem identifier 132496
SMILES O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12
InChiKey VUWXAQFLTSBUDB-UHFFFAOYSA-N

References for FGIN-1-27

References are publications that support the biological activity of the product
  • 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

    Romeo E et al (1992) J Pharmacol Exp Ther 262(3) : 971-8.
  • Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.

    Chung JY et al (2013) Endocrinology 154(6) : 2156-65.
  • Development of ligands for the peripheral benzodiazepine receptor.

    James ML et al (2006) Curr Med Chem 13(17) : 1991-2001.
  • Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo.

    Korneyev A et al (1993) J Neurochem 61(4) : 1515-24.