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FGIN-1-27

(HB0913)
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Product overview

Name FGIN-1-27
Purity >98%
Description Potent, selective MDR receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Potent and selective mitochondrial diazepam binding inhibitor receptor (MDR) agonist, also known as peripheral benzodiazepine receptors. Increase Leydig cell steroid and neurosteroid production. Indirectly modulates GABAA receptors by increasing neurosteroids. Shows anti-convulsant actions. Blood-brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
Molecular Weight 436.61
Chemical structure FGIN-1-27 [142720-24-9] Chemical Structure
Molecular Formula C28H37FN2O
CAS Number 142720-24-9
PubChem identifier 132496
SMILES O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12
InChiKey VUWXAQFLTSBUDB-UHFFFAOYSA-N

References for FGIN-1-27

References are publications that support the biological activity of the product

  • Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.

    Chung JY et al (2013) Endocrinology 154(6) : 2156-65.
    Read more (PubMedID: 23525219)

  • Development of ligands for the peripheral benzodiazepine receptor.

    James ML et al (2006) Curr Med Chem 13(17) : 1991-2001.
    Read more (PubMedID: 16842193)

  • Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo.

    Korneyev A et al (1993) J Neurochem 61(4) : 1515-24.
    Read more (PubMedID: 8397297)

  • 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

    Romeo E et al (1992) J Pharmacol Exp Ther 262(3) : 971-8.
    Read more (PubMedID: 1326631)

4 Item(s)

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Order: HB0913
Pack PriceQty
25mg
$155
Potent, selective MDR receptor agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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