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Biological Data
| Biological description | Potent and selective mitochondrial diazepam binding inhibitor receptor (MDR) agonist, also known as peripheral benzodiazepine receptors. Increase Leydig cell steroid and neurosteroid production. Indirectly modulates GABAA receptors by increasing neurosteroids. Shows anti-convulsant actions. Blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide |
| Chemical structure | ![FGIN-1-27 [142720-24-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "FGIN-1-27 [142720-24-9]") |
| Molecular Formula | C28H37FN2O |
| PubChem identifier | 132496 |
| SMILES | O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12 |
| InChiKey | VUWXAQFLTSBUDB-UHFFFAOYSA-N |
References for FGIN-1-27
References are publications that support the biological activity of the product
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Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.
Chung JY et al (2013) Endocrinology 154(6) : 2156-65. -
Development of ligands for the peripheral benzodiazepine receptor.
James ML et al (2006) Curr Med Chem 13(17) : 1991-2001. -
Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo.
Korneyev A et al (1993) J Neurochem 61(4) : 1515-24. -
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
Romeo E et al (1992) J Pharmacol Exp Ther 262(3) : 971-8.
Potent, selective MDR receptor agonist
![FGIN-1-27 [142720-24-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0913.png "FGIN-1-27 [142720-24-9]")
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