Fasudil hydrochloride product vial image | Hello Bio
Fasudil hydrochloride product vial image | Hello Bio
Biological Data
Biological description
Rho-associated kinase inhibitor (IC50 = 10.7 µM) and cyclic nucleotide-dependent protein kinase inhibitor. Inhibits NOS in microglia and pro-inflammatory factors in brain tissue. Also reduces nitric oxide, IL-1β, IL-6 and TNF. Shows antioxidant effects which can reverse hypertension and neuroprotective actions.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in water (100mM) and in DMSO (75mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Fasudil reversed MCT-induced and chronic hypoxia-induced pulmonary hypertension by attenuating oxidative stress and inhibiting the expression of Trx1 and HIF-1α.
Liu M et al (2014) Respir Physiol Neurobiol 201 : 38-46.
Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
![Fasudil hydrochloride [105628-07-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0283.png "Fasudil hydrochloride [105628-07-7]")
Understanding purity and quality - a guide for life scientists
