Product overview

Name Etomidate
Description Potent GABAA receptor positive allosteric modulator
Purity >99%
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Biological Data

Biological description Potent GABAA receptor positive allosteric modulator. Selective for β2 and β3 subunits (EC50 values are 0.6, 0.7 and 7.4 µM for α6β2γ2, α6β3γ2 and α6β1γ2 GABAA receptor subtypes respectively). Shows short acting hypnotic actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (100mM) and in 1M HCl (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Molecular Weight 244.29
Chemical structure Etomidate  [33125-97-2] Chemical Structure
Molecular Formula C14H16N2O2
CAS Number 33125-97-2
PubChem identifier 36339
SMILES CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
InChi InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3
InChiKey NPUKDXXFDDZOKR-UHFFFAOYSA-N
MDL number MFCD00869295

References for Etomidate

References are publications that support the biological activity of the product
  • Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors.

    Drexler B et al (2009) Neuropharmacology 57(4) : 446-55.
  • Etomidate and other non-barbiturates.

    Vanlersberghe C et al (2008) Handb Exp Pharmacol -182 : 267-82.
  • The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

    Belelli D et al (1997) Proc Natl Acad Sci U S A 94(20) : 11031-6.

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