Product overview
| Name | Etomidate |
| Description | Potent GABAA receptor positive allosteric modulator |
| Purity | >99% |
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Biological Data
| Biological description | Potent GABAA receptor positive allosteric modulator. Selective for β2 and β3 subunits (EC50 values are 0.6, 0.7 and 7.4 µM for α6β2γ2, α6β3γ2 and α6β1γ2 GABAA receptor subtypes respectively). Shows short acting hypnotic actions. Blood-brain barrier permeable. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in ethanol (100mM) and in 1M HCl (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester |
| Molecular Weight | 244.29 |
| Chemical structure | ![Etomidate [33125-97-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0937.png "Etomidate [33125-97-2]") |
| Molecular Formula | C14H16N2O2 |
| CAS Number | 33125-97-2 |
| PubChem identifier | 36339 |
| SMILES | CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2 |
| InChi | InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3 |
| InChiKey | NPUKDXXFDDZOKR-UHFFFAOYSA-N |
| MDL number | MFCD00869295 |
References for Etomidate
References are publications that support the biological activity of the product
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Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors.
Drexler B et al (2009) Neuropharmacology 57(4) : 446-55. -
Etomidate and other non-barbiturates.
Vanlersberghe C et al (2008) Handb Exp Pharmacol -182 : 267-82. -
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.
Belelli D et al (1997) Proc Natl Acad Sci U S A 94(20) : 11031-6.
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