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Endothelin 1 (human, porcine)

Technical documents: SDS CoA Datasheet

Product overview

Name Endothelin 1 (human, porcine)
Biological description

Endothelin 1 is an endogenous neuropeptide which is secreted by endothelial cells.

Endothelin 1 acts through the ETA and ETB receptors and is a potent vasoconstrictor. It has a range of biological actions.

Alternative names ET-1,Edn1
Purity >95%
Description Endogenous vasoconstrictor neuropeptide
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name CSCSSLMDKECVYFCHLDIIW (Disulfide bridge between 1 - 15, 3 - 11)
Molecular Weight 2491.91
Chemical structure Endothelin 1 (human, porcine) [117399-94-7] Chemical Structure
Molecular Formula C109H159N25O32S5
Sequence (three letter) Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp
Modifications Disulfide bridge between 1 - 15, 3 - 11
CAS Number 117399-94-7
PubChem identifier 16133807
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC5=O)CO)CO)CC(C)C)CCSC)CC(=O)O)CCCCN)CCC(=O)O)CO)N
MDL number MFCD00133305
Protein length 21

References for Endothelin 1 (human, porcine)

References are publications that support the biological activity of the product
  • Endothelin-1: Biosynthesis, Signaling and Vasoreactivity.

    Houde et al (2016) Adv Pharmacol 77 : 143-75
  • The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis.

    Kowalczyk et al (2015) Arch Immunol Ther Exp (Warsz) 63(1) : 41-52
  • Endothelin-1: the yin and yang on vascular function.

    Marasciulo et al (2006) Curr Med Chem 13(14) : 1655-65

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