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BQ-123

(HB3213)
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Technical documents: SDS CoA Datasheet
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Product overview

Name BQ-123
Biological description

BQ-123 is a potent and selective ETA antagonist (Ki values are 17 nM and 11 µM at ETA and ETB receptors respectively).

Induces vasodilation.

Purity >95%
Description Potent, selective ETA antagonist
Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (4) Frequently bought together
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.4 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name WDPVL (modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)
Molecular Weight 610.71
Chemical structure BQ-123 | [136553-81-6] Chemical Structure
Molecular Formula C31H42N6O7
Sequence (one letter) WDPVL
Modifications Trp-1 = D-Trp, Val-4 = D-Val, Cyclized
CAS Number 136553-81-6
PubChem identifier 443289
SMILES CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
InChiKey VYCMAAOURFJIHD-PJNXIOHISA-N
MDL number MFCD00133204

References for BQ-123

References are publications that support the biological activity of the product

  • Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues

    Maguire JJ et al (2012) Life Sci 91(13-14) : 681-6
    Read more (PubMedID: 22634326)

  • Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

    Leslie SJ et al (2004) Br J Clin Pharmacol 57(6) : 720-5
    Read more (PubMedID: 15151517)

  • Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF

    Warner TD et al (1993) Br J Pharmacol 110(2) : 777-82
    Read more (PubMedID: 8242251)

  • In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor

    Ihara M et al (1992) J Cardiovasc Pharmacol 20 Suppl 12 : S11-4
    Read more (PubMedID: 1282942)

4 Item(s)

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Order: HB3213
Pack PriceQty
500μg
$145
Potent, selective ETA antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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