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Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (0.4 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name WDPVL (modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)
Chemical structure
Molecular Formula C31 H42 N6 O7
Sequence (one letter) WDPVL
Modifications Trp-1 = D-Trp, Val-4 = D-Val, Cyclized
PubChem identifier 443289
SMILES CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
InChiKey VYCMAAOURFJIHD-PJNXIOHISA-N
References for BQ-123 References are publications that support the biological activity of the product
Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues Maguire JJ et al (2012) Life Sci 91(13-14) : 681-6 Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide Leslie SJ et al (2004) Br J Clin Pharmacol 57(6) : 720-5 Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF Warner TD et al (1993) Br J Pharmacol 110(2) : 777-82 In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor Ihara M et al (1992) J Cardiovasc Pharmacol 20 Suppl 12 : S11-4
Potent, selective ETA antagonist
![BQ-123 | [136553-81-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3213_1.png "BQ-123 | [136553-81-6]")
Understanding purity and quality - a guide for life scientists
