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Technical documents: SDS CoA Datasheet

Product overview

Name BQ-123
Biological description

BQ-123 is a potent and selective ETA antagonist (Ki values are 17 nM and 11 µM at ETA and ETB receptors respectively).

Induces vasodilation.

Purity >95%
Description Potent, selective ETA antagonist
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Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (0.4 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name WDPVL (modifications: Trp-1 = D-Trp, Val-4 = D-Val, Cyclized)
Molecular Weight 610.71
Chemical structure BQ-123 | [136553-81-6] Chemical Structure
Molecular Formula C31H42N6O7
Sequence (one letter) WDPVL
Modifications Trp-1 = D-Trp, Val-4 = D-Val, Cyclized
CAS Number 136553-81-6
PubChem identifier 443289
SMILES CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
MDL number MFCD00133204

References for BQ-123

References are publications that support the biological activity of the product
  • Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues

    Maguire JJ et al (2012) Life Sci 91(13-14) : 681-6
  • Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide

    Leslie SJ et al (2004) Br J Clin Pharmacol 57(6) : 720-5
  • Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF

    Warner TD et al (1993) Br J Pharmacol 110(2) : 777-82
  • In vitro biological profile of a highly potent novel endothelin (ET) antagonist BQ-123 selective for the ETA receptor

    Ihara M et al (1992) J Cardiovasc Pharmacol 20 Suppl 12 : S11-4

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