Product overview

Name Endothelin 2 (human)
Biological description


Endothelin 2 is an endogenous neuropeptide which has the same affinity as endothelin 1 (ET-1) for both the ETA and ETB receptors.

It tightly binds to smooth muscle ETA receptors to causes potent, long-lasting vasoconstriction.

Uses & applications

It has been shown to have a key role in ovarian physiology and has also been implicated in immunology, cancer and the cardiovascular system.

Alternative names ET-2, Edn2, VIC
Purity >95%
Description Vasoconstrictive neuropeptide.
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name CSCSSWLDKECVYFCHLDIIW Disulfide bridge between 1 - 15, 3 - 11
Molecular Weight 2546.94
Chemical structure Endothelin 2 (human) [123562-20-9] Chemical Structure
Molecular Formula C115H160N26O32S4
Sequence (three letter) Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp
Modifications Disulfide bridge between 1 - 15, 3 - 11
CAS Number 123562-20-9
PubChem identifier 16133808
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC5=O)CO)CO)CC8=CNC9=CC=CC=C98)CC(C)C)CC(=O)O)CCCCN)CCC(=O)O)CO)N
MDL number MFCD00133306
Protein length 21

References for Endothelin 2 (human)

References are publications that support the biological activity of the product
  • Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer

    Ling L et al (2013) Br J Pharmacol 168(2) : 283-95
  • Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries

    Compeer MG et al (2013) Br J Pharmacol 170(6) : 1199-209
  • The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

    Inoue A et al (1989) Proc Natl Acad Sci U S A 86(8) : 2863-7

3 Item(s)