Product overview

Name Endothelin 2 (human)
Biological description

Overview

Endothelin 2 is an endogenous neuropeptide which has the same affinity as endothelin 1 (ET-1) for both the ETA and ETB receptors.

It tightly binds to smooth muscle ETA receptors to causes potent, long-lasting vasoconstriction.

Uses & applications

It has been shown to have a key role in ovarian physiology and has also been implicated in immunology, cancer and the cardiovascular system.

Alternative names ET-2, Edn2, VIC
Purity >95%
Description Vasoconstrictive neuropeptide.
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Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1 mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name CSCSSWLDKECVYFCHLDIIW Disulfide bridge between 1 - 15, 3 - 11
Molecular Weight 2546.94
Chemical structure Endothelin 2 (human) [123562-20-9] Chemical Structure
Molecular Formula C115H160N26O32S4
Sequence (one letter) CSCSSWLDKECVYFCHLDIIW
Sequence (three letter) Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp
Modifications Disulfide bridge between 1 - 15, 3 - 11
CAS Number 123562-20-9
PubChem identifier 16133808
SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CC6=CC=CC=C6)CC7=CC=C(C=C7)O)C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC5=O)CO)CO)CC8=CNC9=CC=CC=C98)CC(C)C)CC(=O)O)CCCCN)CCC(=O)O)CO)N
InChiKey MLFJHYIHIKEBTQ-IYRKOGFYSA-N
MDL number MFCD00133306
Protein length 21

References for Endothelin 2 (human)

References are publications that support the biological activity of the product
  • Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer

    Ling L et al (2013) Br J Pharmacol 168(2) : 283-95
  • Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteries

    Compeer MG et al (2013) Br J Pharmacol 170(6) : 1199-209
  • The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

    Inoue A et al (1989) Proc Natl Acad Sci U S A 86(8) : 2863-7

3 Item(s)