Product overview

Name (D)-PPA 1
Description PD-1/PD-L1 interaction inhibitor
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Biological Data

Biological description PD-1/PD-L1 interaction inhibitor (Kd = 0.51µM at PD-L1). Inhibits tumor growth and prolongs survival time of mice in vivo.

Solubility & Handling

Solubility overview Soluble in water (2 mg/ml)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Molecular Weight 1555.67
Molecular Formula C70H98N20O21
CAS Number 1620813-53-7

References for (D)-PPA 1

References are publications that support the biological activity of the product
  • PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer.

    Sun Z et al (2018) Drug delivery 25 : 1746-1755
  • Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy.

    Chang HN et al (2015) Angewandte Chemie (International ed. in English) 54 : 11760-4

2 Item(s)