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Cisplatin

(HB1289)
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Product overview

Name Cisplatin
Alternative names CDDP
Description Broad spectrum anticancer agent. Apoptosis inducer.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description

Broad spectrum anticancer agent which induces apoptosis. Widely used in studies on DNA damage-induced apoptosis. Induces cytotoxicity by interference with transcription / DNA replication mechanisms.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (5mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name cis-Diaminodichloroplatinum
Molecular Weight 300.05
Molecular Formula Cl2H6N2Pt
CAS Number 15663-27-1
PubChem identifier 84691
SMILES N.N.[Cl-].[Cl-].[Pt++]
InChiKey LXZZYRPGZAFOLE-UHFFFAOYSA-L

References for Cisplatin

References are publications that support the biological activity of the product

  • Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.

    van Waardenburg RC et al (2004) J Biol Chem 279(52) : 54502-9.
    Read more (PubMedID: 15471886)

  • Cisplatin: mode of cytotoxic action and molecular basis of resistance.

    Siddik ZH (2003) Oncogene 22(47) : 7265-79.
    Read more (PubMedID: 14576837)

  • Biomolecular targets for platinum antitumor drugs.

    Bose RN (2002) Mini Rev Med Chem 2(2) : 103-11.
    Read more (PubMedID: 12370072)

  • Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma.

    Seki K et al (2000) Cancer Chemother Pharmacol 45(3) : 199-206.
    Read more (PubMedID: 10663637)

4 Item(s)

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Grouped product items
Order: HB1289
Pack PriceQty
50mg
$106
250mg
$424
Broad spectrum anticancer agent. Apoptosis inducer.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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