The store will not work correctly in the case when cookies are disabled.
Images
CGP 37157 product vial image | Hello Bio
CGP 37157 product vial image | Hello Bio
Biological Data
| Biological description | Potent and selective mitochondria Na+ / Ca2+ exchange inhibitor (IC50 = 0.36 µM). Also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and activates ryanodine receptor channels (RyRs) (EC50 values are 9.4 and 12.0 µM for cardiac and skeletal RyRs respectively). Displays neuroprotective properties. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
| Chemical structure | ![CGP 37157 [75450-34-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CGP 37157 [75450-34-9]") |
| Molecular Formula | C15H11Cl2NOS |
| SMILES | C1C(=O)NC2=C(C=C(C=C2)Cl)C(S1)C3=CC=CC=C3Cl |
| InChi | InChI=1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19) |
| InChiKey | KQEPIRKXSUIUTH-UHFFFAOYSA-N |
References for CGP 37157
References are publications that support the biological activity of the product
-
CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels.
Ruiz A et al (2014) Cell Death Dis 5 : e1156. -
Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.
González-Lafuente L et al (2012) ACS Chem Neurosci 3(7) : 519-29. -
CGP-37157 inhibits the sarcoplasmic reticulum Ca?+ ATPase and activates ryanodine receptor channels in striated muscle.
Neumann JT et al (2011) Mol Pharmacol 79(1) : 141-7. -
Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157.
Cox DA et al (1993) J Cardiovasc Pharmacol 21(4) : 595-9.
Potent, selective mitochondria Na+ / Ca2+ exchange inhibitor
![CGP 37157 [75450-34-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1132.png "CGP 37157 [75450-34-9]")
Understanding purity and quality - a guide for life scientists
