Product overview

Name BLZ-945
Purity >95%
Description Potent, selective colony stimulating factor 1 receptor (CSF-1R) inhibitor
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Biological Data

Biological description Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R) inhibitor. More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor beta (PDGFRbeta). Selective against more than 200 additional kinases.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >95%
Chemical name 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide
Molecular Weight 398.5
Chemical structure BLZ-945 [953769-46-5] Chemical Structure
Molecular Formula C20H22N4O3S
CAS Number 953769-46-5
PubChem identifier 46184986
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)N[C@@H]4CCCC[C@H]4O
InChi InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1
InChiKey ADZBMFGQQWPHMJ-RHSMWYFYSA-N
MDL number MFCD28142668
Appearance Pale yellow solid