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Amiloride hydrochloride

(HB1010)
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Product overview

Name Amiloride hydrochloride
Purity >98%
Description Na+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Na+ channel blocker. Acid sensing ion channel (ASIC) blocker, protects cells from metabolic acidosis injury associated with ischemia. Inhibits TRPP3-mediated Ca2+ channel transport (IC50 = 143 µM). Shows antiviral and anticancer actions.

Solubility & Handling

Solubility overview Soluble in water (10mM, gentle warming)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
Molecular Weight 266.09
Chemical structure Amiloride hydrochloride [2016-88-8] Chemical Structure
Molecular Formula C6H8ClN7O.HCl
CAS Number 2016-88-8
PubChem identifier 16230
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl
InChi InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChiKey ACHKKGDWZVCSNH-UHFFFAOYSA-N
MDL number MFCD03703482

References for Amiloride hydrochloride

References are publications that support the biological activity of the product

  • Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts.

    Guan B et al (2014) Front Biol (Beijing) 9(1) : 75-81.
    Read more (PubMedID: 24999355)

  • Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.

    Jetti SK et al (2010) Nitric Oxide 22(3) : 213-9.
    Read more (PubMedID: 20045740)

  • Inhibition of TRPP3 channel by amiloride and analogs.

    Dai XQ et al (2007) Mol Pharmacol 72(6) : 1576-85.
    Read more (PubMedID: 17804601)

  • Amiloride and its analogs as tools in the study of ion transport.

    Kleyman TR et al (1988) J Membr Biol 105(1) : 1-21.
    Read more (PubMedID: 2852254)

4 Item(s)

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Order: HB1010
Pack PriceQty
100mg
$51
Na+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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