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Biological Data
| Biological description | Na+ channel blocker. Acid sensing ion channel (ASIC) blocker, protects cells from metabolic acidosis injury associated with ischemia. Inhibits TRPP3-mediated Ca2+ channel transport (IC50 = 143 µM). Shows antiviral and anticancer actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (10mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride |
| Chemical structure | ![Amiloride hydrochloride [2016-88-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Amiloride hydrochloride [2016-88-8]") |
| Molecular Formula | C6H8ClN7O.HCl |
| SMILES | C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl |
| InChi | InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H |
| InChiKey | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
References for Amiloride hydrochloride
References are publications that support the biological activity of the product
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Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts.
Guan B et al (2014) Front Biol (Beijing) 9(1) : 75-81. -
Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.
Jetti SK et al (2010) Nitric Oxide 22(3) : 213-9. -
Inhibition of TRPP3 channel by amiloride and analogs.
Dai XQ et al (2007) Mol Pharmacol 72(6) : 1576-85. -
Amiloride and its analogs as tools in the study of ion transport.
Kleyman TR et al (1988) J Membr Biol 105(1) : 1-21.
![Amiloride hydrochloride [2016-88-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1010_2.png "Amiloride hydrochloride [2016-88-8]")
Understanding purity and quality - a guide for life scientists
