Product overview

Name Amiloride hydrochloride
Purity >98%
Description Na+ channel blocker
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Biological Data

Biological description Na+ channel blocker. Acid sensing ion channel (ASIC) blocker, protects cells from metabolic acidosis injury associated with ischemia. Inhibits TRPP3-mediated Ca2+ channel transport (IC50 = 143 µM). Shows antiviral and anticancer actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
Molecular Weight 266.09
Chemical structure Amiloride hydrochloride  [2016-88-8] Chemical Structure
Molecular Formula C6H8ClN7O.HCl
CAS Number 2016-88-8
PubChem identifier 16230
SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl
InChi InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
MDL number MFCD03703482

References for Amiloride hydrochloride

References are publications that support the biological activity of the product
  • Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts.

    Guan B et al (2014) Front Biol (Beijing) 9(1) : 75-81.
  • Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death.

    Jetti SK et al (2010) Nitric Oxide 22(3) : 213-9.
  • Inhibition of TRPP3 channel by amiloride and analogs.

    Dai XQ et al (2007) Mol Pharmacol 72(6) : 1576-85.
  • Amiloride and its analogs as tools in the study of ion transport.

    Kleyman TR et al (1988) J Membr Biol 105(1) : 1-21.

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