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CGP 55845 hydrochloride

(HB0960)
Publications (21)
Technical documents: SDS CoA Datasheet
10  Reviews
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Product overview

Name CGP 55845 hydrochloride
Alternative names CGP 55845, CGP-55845, CGP55845,
Purity >98%
Customer comments

Works great! Switching to Hello Bio CGP 55845 from another supplier has saved us literally hundreds of dollars in the last year without sacrificing any quality at all! Indistinguishable in all regards except price. We love it! Verified customer, University of Toronto

Description Potent, selective GABAB receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (10) Publications (21) References (3) Frequently bought together
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Images

CGP 55845 hydrochloride product vial image | Hello Bio
CGP 55845 hydrochloride product vial image | Hello Bio

CGP 55845 hydrochloride product vial image | Hello Bio

CGP 55845 hydrochloride product vial image | Hello Bio

Biological Data

Biological description

CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM). It inhibits [3H]CGP 27492 binding (pKi = 8.35).


CGP55845 hydrochloride inhibits GABA and glutamate release and inhibits GABAB receptor responses to baclofen (IC50 = 130 nM in an isoproterenol assay).


It enhances responses to hypoglycaemia and shows convulsive actions at high doses.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl)phosphinic acid hydrochloride
Molecular Weight 438.71
Chemical structure CGP 55845 hydrochloride [149184-22-5] Chemical Structure
Molecular Formula C18H22Cl2NO3P.HCl
CAS Number 149184-22-5
PubChem identifier 5311042
SMILES C[C@@H](C1=CC(=C(C=C1)Cl)Cl)NC[C@@H](CP(=O)(CC2=CC=CC=C2)O)O
Source Synthetic
InChi InChI=1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1
InChiKey ZODSPDOOCZZEIM-BBRMVZONSA-N
Appearance White solid

References for CGP 55845 hydrochloride

References are publications that support the biological activity of the product

  • Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body.

    Zhang M et al (2007) J Physiol 578(Pt 3) : 735-50.
    Read more (PubMedID: 17124268)

  • Functional characterization and expression of thalamic GABA(B) receptors in a rodent model of Parkinson's disease.

    de Groote C et al (1999) Neuropharmacology 38(11) : 1683-9.
    Read more (PubMedID: 10587084)

  • GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors.

    Waldmeier PC et al (1994) Br J Pharmacol 113(4) : 1515-21.
    Read more (PubMedID: 7889310)

3 Item(s)

Publications
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These publications cite the use of CGP 55845 hydrochloride purchased from Hello Bio:

  • The dopamine neuron synaptic map in the striatum.

    Chuhma N et al (2023) Cell reports 42 : 112204
    PubMedID: 36867530

  • A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

    Matityahu L et al (2022) Elife 11
    PubMedID: 35579422

  • Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice

    Callahan JW et al (2022) J Neurosci 42(10) : 2080-2102
    PubMedID: 35058372

  • Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders

    Leuffe et al (2021) Transl Psychiatry . : 11(1)
    PubMedID: 34650032

  • Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

    Goldberg et al (2021) bioRxiv https://doi.org/10.1101/2021.11.29.470423 : doi

Items 1 to 5 of 21 total

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10mg
$190
50mg
$790
Potent, selective GABAB receptor antagonist
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