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Images TRAM 34 product vial image | Hello Bio
TRAM 34 product vial image | Hello Bio Biological Data Biological description Potent and selective KCa 3.1 channel blocker (IC50 = 18 nM and Kd = 20 nM). Exhibits approx 200 to 1,500-fold less effect at Kv 1.1-1.5, Kv 3.1, Kv 4.2, Kir 2.1 and KCa 1.1 channels. Displays anti-tumor properties and suppresses T-cell mitogenesis. Blood brain barrier and membrane permeable.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (50mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1-[(2-Chlorophenyl)diphenylmethyl]-1H -pyrazole
Chemical structure
Molecular Formula C22 H17 ClN2
PubChem identifier 656734
SMILES ClC(C=CC=C4)=C4C(N2C=CC=N2)(C3=CC=CC=C3)C1=CC=CC=C1
InChiKey KBFUQFVFYYBHBT-UHFFFAOYSA-N
References for TRAM 34 References are publications that support the biological activity of the product
The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB. Freise C et al (2013) Invest New Drugs 31(2) : 452-7. The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke. Chen YJ et al (2011) J Cereb Blood Flow Metab 31(12) : 2363-74. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. Toyama K et al (2008) J Clin Invest 118(9) : 3025-37. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Wulff H et al (2000) Proc Natl Acad Sci U S A 97(14) : 8151-6.
Publications
These publications cite the use of TRAM 34 purchased from Hello Bio:
Nav1. 2 and BK channels interaction shapes the action potential in the axon initial segment Canepari et al (2022) Biorxiv : https://doi.org/10.1101/2022.04.12.488116
Potent, selective KCa 3.1 channel blocker
![TRAM 34 [289905-88-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1058.png "TRAM 34 [289905-88-0]")
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