Potent and selective KCa3.1 channel blocker (IC50 = 18 nM and Kd = 20 nM). Exhibits approx 200 to 1,500-fold less effect at Kv1.1-1.5, Kv3.1, Kv4.2, Kir2.1 and KCa1.1 channels. Displays anti-tumor properties and suppresses T-cell mitogenesis. Blood brain barrier and membrane permeable.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM) or ethanol (10mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB.
Freise C et al (2013) Invest New Drugs 31(2) : 452-7.