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TRAM 34

(HB1058)
Publications (1)
Technical documents: SDS Datasheet
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Product overview

Name TRAM 34
Purity >99%
Description Potent, selective KCa3.1 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) Publications (1) References (4) Frequently bought together
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TRAM 34 product vial image | Hello Bio
TRAM 34 product vial image | Hello Bio

TRAM 34 product vial image | Hello Bio

TRAM 34 product vial image | Hello Bio

Biological Data

Biological description Potent and selective KCa3.1 channel blocker (IC50 = 18 nM and Kd = 20 nM). Exhibits approx 200 to 1,500-fold less effect at Kv1.1-1.5, Kv3.1, Kv4.2, Kir2.1 and KCa1.1 channels. Displays anti-tumor properties and suppresses T-cell mitogenesis. Blood brain barrier and membrane permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (50mM) or ethanol (10mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Molecular Weight 344.84
Chemical structure TRAM 34 [289905-88-0] Chemical Structure
Molecular Formula C22H17ClN2
CAS Number 289905-88-0
PubChem identifier 656734
SMILES ClC(C=CC=C4)=C4C(N2C=CC=N2)(C3=CC=CC=C3)C1=CC=CC=C1
InChiKey KBFUQFVFYYBHBT-UHFFFAOYSA-N

References for TRAM 34

References are publications that support the biological activity of the product

  • The inhibitor of Ca(2+)-dependent K+ channels TRAM-34 blocks growth of hepatocellular carcinoma cells via downregulation of estrogen receptor alpha mRNA and nuclear factor-kappaB.

    Freise C et al (2013) Invest New Drugs 31(2) : 452-7.
    Read more (PubMedID: 23054207)

  • The KCa3.1 blocker TRAM-34 reduces infarction and neurological deficit in a rat model of ischemia/reperfusion stroke.

    Chen YJ et al (2011) J Cereb Blood Flow Metab 31(12) : 2363-74.
    Read more (PubMedID: 21750563)

  • The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans.

    Toyama K et al (2008) J Clin Invest 118(9) : 3025-37.
    Read more (PubMedID: 18688283)

  • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.

    Wulff H et al (2000) Proc Natl Acad Sci U S A 97(14) : 8151-6.
    Read more (PubMedID: 10884437)

4 Item(s)

Publications
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These publications cite the use of TRAM 34 purchased from Hello Bio:

  • Nav1. 2 and BK channels interaction shapes the action potential in the axon initial segment

    Canepari et al (2022) Biorxiv : https://doi.org/10.1101/2022.04.12.488116

1 Item

Grouped product items
Order: HB1058
Pack PriceQty
10mg
$112
25mg
$222
Potent, selective KCa3.1 channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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