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TC-H 106

(HB1400)
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Product overview

Name TC-H 106
Alternative names Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106
Purity >99%
Description Selective class I HDAC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective class I histone deacetylase (HDAC) inhibitor. Inhibits HDAC1, HDAC3, HDAC2 and HDAC8 (IC50 values are 150, 370, 760 and 5000 nM respectively). Shows slow tight-binding inhibition of HDAC1, 2 and 3. Shows actions against neurodegenerative diseases. Blood-brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (50mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N1-(2-Aminophenyl)-N7-(4-methylphen yl)heptanediamide
Molecular Weight 339.43
Chemical structure TC-H 106 [937039-45-7] Chemical Structure
Molecular Formula C20H25N3O2
CAS Number 937039-45-7
PubChem identifier 16070100
SMILES NC1=CC=CC=C1NC(CCCCCC(NC2=CC=C(C)C=C2)=O)=O
InChiKey WTKBRPXPNAKVEQ-UHFFFAOYSA-N

References for TC-H 106

References are publications that support the biological activity of the product

  • Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.

    Xu C et al (2009) Chem Biol 16(9) : 980-9.
    Read more (PubMedID: 19778726)

  • Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.

    Chou CJ et al (2008) J Biol Chem 283(51) : 35402-9.
    Read more (PubMedID: 18953021)

  • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

    Rai M et al (2008) PLoS One 3(4) : e1958.
    Read more (PubMedID: 18463734)

3 Item(s)

Grouped product items
Order: HB1400
Pack PriceQty
50mg
$950
Selective class I HDAC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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