Potent, selective and cell permeable yeast NAD+-dependent histone deacetylase (HDAC) Sir2p inhibitor. Displays higher activity in vivo than in vitro. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Shown to have diverse effects also in mammalian cells.
Solubility & Handling
Storage instructions
+4°C
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![Splitomicin [5690-03-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4091.png "Splitomicin [5690-03-9]")
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