Selective reverse transcriptase inhibitor which exhibits 100-fold selectivity for HIV reverse transcriptase compared to DNA polymerase α. Blocks HIV replication and exhibits anti-HIV activity. Orally bioavailable and brain penetrant. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency and enhances gene knockout efficiency.
Solubility & Handling
Solubility overview
Soluble in water (50 mM) and in DMSO (100 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
Mitsuya et al (1985) Proc Natl Acad Sci U S A 82(20) : 7096-100