Product overview
| Name | Azidothymidine |
| Description | Selective reverse transcriptase inhibitor with anti-HIV activity. Decreases CRISPR-mediated homology directed repair (HDR) and enhances gene knockout efficiency. |
| Alternative names | AZT, ZDV |
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Biological Data
| Biological description | Selective reverse transcriptase inhibitor which exhibits 100-fold selectivity for HIV reverse transcriptase compared to DNA polymerase α. Blocks HIV replication and exhibits anti-HIV activity. Orally bioavailable and brain penetrant. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency and enhances gene knockout efficiency. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (50 mM) and in DMSO (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3'-Azido-3'-deoxythymidine |
| Molecular Weight | 267.2 |
| Chemical structure | ![Azidothymidine [30516-87-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4602.png "Azidothymidine [30516-87-1]") |
| Molecular Formula | C10H13N5O4 |
| CAS Number | 30516-87-1 |
| PubChem identifier | 5726 |
| SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-] |
| InChi | InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18) |
| InChiKey | HBOMLICNUCNMMY-UHFFFAOYSA-N |
| MDL number | MFCD00006536 |
| Appearance | White solid |
References for Azidothymidine
References are publications that support the biological activity of the product
-
Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al (2015) Cell Stem Cell 16(2) : 142-7 -
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.
Broder (2010) Antiviral Res 85(1) : 1-18 -
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
Mitsuya et al (1985) Proc Natl Acad Sci U S A 82(20) : 7096-100
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