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Azidothymidine

(HB4602)
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Product overview

Name Azidothymidine
Alternative names AZT, ZDV
Purity >98%
Description Selective reverse transcriptase inhibitor with anti-HIV activity. Decreases CRISPR-mediated homology directed repair (HDR) and enhances gene knockout efficiency.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective reverse transcriptase inhibitor which exhibits 100-fold selectivity for HIV reverse transcriptase compared to DNA polymerase α. Blocks HIV replication and exhibits anti-HIV activity. Orally bioavailable and brain penetrant. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency and enhances gene knockout efficiency.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (50 mM) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 3'-Azido-3'-deoxythymidine
Molecular Weight 267.2
Chemical structure Azidothymidine [30516-87-1] Chemical Structure
Molecular Formula C10H13N5O4
CAS Number 30516-87-1
PubChem identifier 5726
SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
InChi InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)
InChiKey HBOMLICNUCNMMY-UHFFFAOYSA-N
MDL number MFCD00006536
Appearance White solid

References for Azidothymidine

References are publications that support the biological activity of the product

  • Small molecules enhance CRISPR genome editing in pluripotent stem cells.

    Yu et al (2015) Cell Stem Cell 16(2) : 142-7
    Read more (PubMedID: 25658371)

  • The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.

    Broder (2010) Antiviral Res 85(1) : 1-18
    Read more (PubMedID: 20018391)

  • 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

    Mitsuya et al (1985) Proc Natl Acad Sci U S A 82(20) : 7096-100
    Read more (PubMedID: 2413459)

3 Item(s)

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Order: HB4602
Pack PriceQty
50mg
$47
250mg
$188
Selective reverse transcriptase inhibitor with anti-HIV activity. Decreases CRISPR-mediated homology directed repair (HDR) and enhances gene knockout efficiency.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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