Product overview
Name | Azidothymidine |
Description | Selective reverse transcriptase inhibitor with anti-HIV activity. Decreases CRISPR-mediated homology directed repair (HDR) and enhances gene knockout efficiency. |
Alternative names | AZT, ZDV |
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Biological Data
Biological description | Selective reverse transcriptase inhibitor which exhibits 100-fold selectivity for HIV reverse transcriptase compared to DNA polymerase α. Blocks HIV replication and exhibits anti-HIV activity. Orally bioavailable and brain penetrant. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency and enhances gene knockout efficiency. |
Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (50 mM) and in DMSO (100 mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 3'-Azido-3'-deoxythymidine |
Molecular Weight | 267.2 |
Chemical structure | |
Molecular Formula | C10H13N5O4 |
CAS Number | 30516-87-1 |
PubChem identifier | 5726 |
SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-] |
InChi | InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18) |
InChiKey | HBOMLICNUCNMMY-UHFFFAOYSA-N |
MDL number | MFCD00006536 |
Appearance | White solid |
References for Azidothymidine
References are publications that support the biological activity of the product
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Small molecules enhance CRISPR genome editing in pluripotent stem cells.
Yu et al (2015) Cell Stem Cell 16(2) : 142-7 -
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic.
Broder (2010) Antiviral Res 85(1) : 1-18 -
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
Mitsuya et al (1985) Proc Natl Acad Sci U S A 82(20) : 7096-100