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Biological Data
| Biological description | Potent histone deacetylase (HDAC) inhibitor (ID50 = 100 nM for HDAC1). Increases p21/WAF expression and shows growth inhibitory actions in cancer cells. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-Hydroxy-N'-3-pyridinyloctanediamid e |
| Chemical structure | ![Pyroxamide [382180-17-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Pyroxamide [382180-17-8]") |
| Molecular Formula | C13H19N3O3 |
| SMILES | O=C(CCCCCCC(NO)=O)NC1=CC=CN=C1 |
| InChiKey | PTJGLFIIZFVFJV-UHFFFAOYSA-N |
References for Pyroxamide
References are publications that support the biological activity of the product
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Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.
Kutko MC et al (2003) Clin Cancer Res 9(15) : 5749-55. -
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
Butler LM et al (2001) Clin Cancer Res 7(4) : 962-70.
![Pyroxamide [382180-17-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1395.png "Pyroxamide [382180-17-8]")
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